ACYP2, acylphosphatase 2, 98

N. diseases: 42; N. variants: 20
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs55930424
rs55930424
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs843750
rs843750
Entrez Id: 98;105374610
Gene Symbol: ACYP2;LOC105374610
ACYP2;LOC105374610
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs9808326
rs9808326
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs1075265
rs1075265
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0008810
Disease:
Circadian Rhythms 		G 0.700 GeneticVariation GWASCAT Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
dbSNP: rs17189743
rs17189743
Entrez Id: 98;388951
Gene Symbol: ACYP2;TSPYL6
ACYP2;TSPYL6
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.700 GeneticVariation GWASCAT Exome-wide association study of plasma lipids in >300,000 individuals. 29083408 2017
dbSNP: rs1075265
rs1075265
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0008810
Disease:
Circadian Rhythms 		C 0.700 GeneticVariation GWASCAT Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci. 27494321 2016
dbSNP: rs1075265
rs1075265
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0008810
Disease:
Circadian Rhythms 		G 0.700 GeneticVariation GWASCAT Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci. 27494321 2016
dbSNP: rs1559040
rs1559040
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C1720824
Disease:
Sudden Cardiac Arrest 		0.700 GeneticVariation GWASDB GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. 21658281 2011
dbSNP: rs1559040
rs1559040
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0085298
Disease:
Sudden Cardiac Death 		0.700 GeneticVariation GWASCAT GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. 21658281 2011
dbSNP: rs11125529
rs11125529
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0008707
Disease:
Chronic osteomyelitis 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0279000
Disease:
Liver and Intrahepatic Biliary Tract Carcinoma 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0345904
Disease:
Malignant neoplasm of liver 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0220630
Disease:
Adult Liver Carcinoma 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs843645
rs843645
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0220630
Disease:
Adult Liver Carcinoma 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs843645
rs843645
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0279000
Disease:
Liver and Intrahepatic Biliary Tract Carcinoma 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs843645
rs843645
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0345904
Disease:
Malignant neoplasm of liver 		0.020 GeneticVariation BEFREE Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027). 31124313 2019
dbSNP: rs843720
rs843720
Entrez Id: 98;105374610
Gene Symbol: ACYP2;LOC105374610
ACYP2;LOC105374610
CUI: C0220630
Disease:
Adult Liver Carcinoma 		0.020 GeneticVariation BEFREE In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04). 31124313 2019
dbSNP: rs843720
rs843720
Entrez Id: 98;105374610
Gene Symbol: ACYP2;LOC105374610
ACYP2;LOC105374610
CUI: C0279000
Disease:
Liver and Intrahepatic Biliary Tract Carcinoma 		0.020 GeneticVariation BEFREE In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04). 31124313 2019
dbSNP: rs843720
rs843720
Entrez Id: 98;105374610
Gene Symbol: ACYP2;LOC105374610
ACYP2;LOC105374610
CUI: C0345904
Disease:
Malignant neoplasm of liver 		0.020 GeneticVariation BEFREE In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04). 31124313 2019
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Minor allele of rs1682111 and rs10439478 and its interaction were associated with increased BC risk. 29033240 2018
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Minor allele of rs1682111 and rs10439478 and its interaction were associated with increased BC risk. 29033240 2018
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0220630
Disease:
Adult Liver Carcinoma 		0.020 GeneticVariation BEFREE Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population. 28978066 2017
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0345904
Disease:
Malignant neoplasm of liver 		0.020 GeneticVariation BEFREE Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population. 28978066 2017
dbSNP: rs1682111
rs1682111
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0279000
Disease:
Liver and Intrahepatic Biliary Tract Carcinoma 		0.020 GeneticVariation BEFREE Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population. 28978066 2017
dbSNP: rs843645
rs843645
Entrez Id: 98
Gene Symbol: ACYP2
ACYP2
CUI: C0345904
Disease:
Malignant neoplasm of liver 		0.020 GeneticVariation BEFREE We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer. 28978066 2017