|
BODY ACHE
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control.
|
31738228 |
2020 |
|
Bodily Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, patients receiving similar combination therapy (opioid + tricyclic antidepressant) carrying the C allele of rs1045642 displayed 33% fewer body pain sites than patients without that allele, suggesting better pain control.
|
31738228 |
2020 |
|
Deep Vein Thrombosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ABCB1 polymorphism rs1045642 demonstrated statistical significance, albeit only in premenopausal patients, i.e. the effect of two variant alleles on the TTE extension was demonstrated only in the premenopausal group (p=0.0012, HR 0.69; 95% CI 0.21-2.31), and statistical significance (p=0.0106) only for gynaecological/vasomotor AEs (p=0.0221, HR=1.0588), with no evidence of any influence on the incidence and onset of venous complications (i.e. deep venous thrombosis or pulmonary embolism).
|
29135105 |
2019 |
|
Agnosia for Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Assays of plasma concentrations of morphine and metabolites (morphine 3-glucuronide and morphine 6-glucuronide) were performed and common polymorphisms in four candidate genes [OPRM1 A118G rs1799971; P-glycoprotein (ABCB1) T3435C (rs1045642) and G2677T/A (rs2032582); COMT Val 158 Met (rs4680)] were analysed.Morphine was titrated by staff in the postanaesthesia care unit (PACU) and in the ward patient-controlled intravenous analgesia was used for 24 h.
|
29474345 |
2018 |
|
Post transplant diabetes mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygous carriers of POR*28 or wild-type ABCB1 (rs1045642) gene variants were more frequent in PTDM than in control patients with differences close to significance (p = 0.114 and p = 0.066 respectively).
|
29399716 |
2018 |
|
Hepatitis A
|
|
0.010 |
GeneticVariation
|
BEFREE |
In Chinese Han population, rs1045642 C to T variation in ABCB1 was significantly associated with the decreased risk of HAV infection (P < 0.05).
|
29558945 |
2018 |
|
HCV coinfection
|
|
0.010 |
GeneticVariation
|
BEFREE |
According to our findings HCV coinfection and ABCB1 rs1045642 SNP represent independent determinants of severe liver toxicity related to nevirapine.
|
30419834 |
2018 |
|
Marijuana Abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism is associated with tetrahydrocannabinol blood levels in heavy cannabis users.
|
28917442 |
2018 |
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
MDR1 gene C3435T polymorphism in chronic hepatitis C patients.
|
29155127 |
2018 |
|
Gastrointestinal mucositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 rs1045642 was associated with risk of mucositis (P = 0.031), while PIK3R1 rs10515074 and RAPTOR rs9906827 were associated with hyperglycemia and non-infectious pneumonitis (P = 0.016 and 0.024, respectively).
|
28727815 |
2017 |
|
Hyperglycemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 rs1045642 was associated with risk of mucositis (P = 0.031), while PIK3R1 rs10515074 and RAPTOR rs9906827 were associated with hyperglycemia and non-infectious pneumonitis (P = 0.016 and 0.024, respectively).
|
28727815 |
2017 |
|
Mixed cryoglobulinemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013.
|
28453396 |
2017 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant associations were observed between rs1045642 and therapeutic response to etanercept in AS patients.
|
28151874 |
2017 |
|
Glaucoma, Primary Open Angle
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ABCB1 gene polymorphism 3435C>T may be linked to individual differences in response to latanoprost eye drops treatment in POAG patients.
|
27133047 |
2016 |
|
Intraocular pressure disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, ABCB1 gene 3435C>T polymorphism was associated with a remarkably reduced IOP and an improved VA in POAG patients before and after latanoprost eye drops treatment (both P < 0.05).
|
27133047 |
2016 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (β2=1.152, p=0.015).
|
27288795 |
2016 |
|
HER2-positive carcinoma of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T gene polymorphism as a potential biomarker of clinical outcomes in HER2-positive breast cancer patients.
|
27137881 |
2016 |
|
Myopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The evidence from the meta-analysis demonstrated that the ABCB1 C3435T polymorphism may represent a pharmacogenomic biomarker for predicting treatment outcomes in patients on statins and that statin treatment for more than 5 months can increase the risk of myopathy.
|
26438079 |
2015 |
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study suggests that C3435T polymorphisms in the ABCB1 gene are strongly associated with a predisposition to depression development, the severity of depressive symptoms and the effectiveness of therapy with using different groups of antidepressant agents.
|
26664259 |
2015 |
|
Luminal A Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Premenopausal T allele carriers of the 3435 C/T polymorphism showed a 2-fold increased risk of breast cancer with respect to the reference and postmenopausal groups, as well as triple-negative expression regarding the luminal A/B molecular subrogated subtypes.
|
25730063 |
2015 |
|
Connective Tissue Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the effect of itraconazole (ITCZ), a potent inhibitor of CYP3A4 and P-glycoprotein, on the blood concentration 12 h after tacrolimus administration (C 12h) in relation to CYP3A5 6986A>G and ABCB1 3435C>T genotype status in patients with connective tissue disease (CTD).
|
26184414 |
2015 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No differences were found in genotype/allele frequencies in C1236T and C3435T SNPs of ABCB1 and resistance to RMP and ETB in tuberculosis patients (P > 0.05).
|
26067842 |
2015 |
|
Epilepsy, Temporal Lobe
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy.
|
25458099 |
2015 |
|
Hamartoma Syndrome, Multiple
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively).
|
25346426 |
2015 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |