|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls.
|
15542248 |
2004 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The analysis using C1236T or G2677AT genotypes gave similar results, due to linkage of these polymorphisms.PGP polymorphisms may affect the penetration of olanzapine into the central nervous system as seen by a relationship between the 3435T allele, olanzapine plasma levels, and reduction in the positive symptoms of schizophrenia.
|
17038883 |
2006 |
|
Steroid-sensitive nephrotic syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study was aimed at investigating the association between MDR-1 genetic polymorphisms [C1236T, G2677T(A), C3435T] and parameters describing the clinical course and treatment response of childhood steroid-responsive nephrotic syndrome (SRNS).
|
17043887 |
2007 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Overall, the SNPs considered individually or within haplotypes (C1236T-G2677T/A-C3435T) were not significantly associated with childhood ALL.
|
17548681 |
2007 |
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In particular, carriers of the T/T genotype in exon 12 (1236 C-->T) SNP and the T/T genotype in exon 21 (2677G-->T) SNP were most significantly associated with a higher risk for developing MSI-H CRC compared to controls (P=0.01, OR=3.182 and P=0.005, OR=3.594, respectively).
|
18474294 |
2008 |
|
Glioblastoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genotype of the MDR1 exon12 C1236T SNP is a novel independent predictive factor for outcome of temozolomide treatment in glioblastoma patients.
|
18687982 |
2009 |
|
Glioblastoma Multiforme
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genotype of the MDR1 exon12 C1236T SNP is a novel independent predictive factor for outcome of temozolomide treatment in glioblastoma patients.
|
18687982 |
2009 |
|
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype of the MDR1 exon12 C1236T SNP is a novel independent predictive factor for outcome of temozolomide treatment in glioblastoma patients.
|
18687982 |
2009 |
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype of the MDR1 exon12 C1236T SNP is a novel independent predictive factor for outcome of temozolomide treatment in glioblastoma patients.
|
18687982 |
2009 |
|
Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
|
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNP C1236T was significantly (P=0.05) overrepresented in the U</span>C patients.
|
19005421 |
2009 |
|
Crohn Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Five SNPs, rs1128503 (P = 0.02), rs1202184 (P = 0.008), rs1202186 (P = 0.02), rs2091766 (P = 0.03), and rs2235046 (P = 0.03) were nominally associated with noninflammatory CD.
|
19107781 |
2009 |
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Heterozygous carriers for the variants C1236T, rs2235046 (an SNP in intron 16), and G2677T/A showed a lower risk of developing ulcerative colitis (C1236T: odds ratio [OR] = 0.63, 95% confidence interval [CI] = 0.42-0.93, P = 0.03; G2677T/A: OR = 0.59, CI = 0.39-0.89, P = 0.02; and rs2235046: OR = 0.59, 95% CI = 0.38-0.91, P = 0.009) as compared with homozygotes.
|
19685447 |
2009 |
|
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis revealed an association for 2 variants with IBD when stratified for age of onset (C1236T SNP and rs3789243).
|
19685447 |
2009 |
|
hiv-infection/aids
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three single nucleotide polymorphisms (SNPs) in MDR1 have been shown to affect P-gp expression and function, and may affect HIV/AIDS treatment outcome: 1236C>T [G412G, exon-12], 2677G>T/A [A893S/T, exon-21] and 3435C>T [I1145I, exon-26].
|
19819348 |
2010 |
|
Sleep Apnea, Central
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities.
|
20030680 |
2011 |
|
Renal Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities.
|
20030680 |
2011 |
|
Cockayne Syndrome, Type I
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities.
|
20030680 |
2011 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities.
|
20030680 |
2011 |
|
pediatric AIDS
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the MDR1 SNPs C1236T (exon 12) and C3435T (exon 26) affect HIV-1 vertical transmission and progression to pediatric AIDS.
|
20124970 |
2010 |
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC).
|
20533057 |
2010 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |