|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
Infantile nystagmus syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
C1236T polymorphism was associated with steroid resistance in INS children (odds ratio: 2.27, 95 % confidence interval: 1.2-4.4; P = 0.012).
|
27719329 |
2017 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
C1236T genotype may predict changes in pathological features of patients with HCC to a certain extent, and C3435T SNP can be used as one of the prognostic factors of HCC.
|
30779721 |
2019 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significant protection for MDD males carrying the T allele was observed (C1236T: odds ratio (OR)=0.360, 95% confidence interval [CI]: [0.140-0.950], p=0.022; C3435T: OR=0.306, 95% CI: [0.096-0.980], p=0.042; and G2677TA: OR=0.300, 95% CI: [0.100-0.870], p=0.013).
|
24200053 |
2014 |
|
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
ABCB1 1236C>T polymorphism significantly affects the therapeutic efficacy of tarcolimus at 12 weeks under the tight dose-adjusting treatment for ulcerative colitis.
|
28135009 |
2017 |
|
Nephrotic Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
ABCB1 C1236T, ABCB1 G2677 T/A genotype and BMI are probably the factors influencing the clinical efficacy of TAC in treating patients with NS.
|
29615122 |
2018 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 gene rs2032582 and rs1128503 polymorphisms may be associated with the efficacy of etanercept in AS patients.
|
28151874 |
2017 |
|
Multiple Myeloma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, there are three SNPs (rs1045642, rs2032582 and rs1128503) within the most widely studied of these genes, ABCB1, which have been suggested to have a potential impact on OS in PCM and which may form a haplotype in ABCB1. rs1045642 in ABCB1 appears to be the only SNP affecting OS within the PCM patients studied, with minimal linkage disequilibrium demonstrated between it and rs2032582 and rs1128503.
|
21705081 |
2011 |
|
Familial Mediterranean Fever
|
|
0.020 |
GeneticVariation
|
BEFREE |
Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever.
|
22194207 |
2011 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
CC and TC+TT genotype patients with C1236T loci showed statistically significant differences in tumor size stratification (χ=4.006, P=0.045).
|
30779721 |
2019 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Considering genotype analyses, CT (rs1128503) demonstrated an increased chance of anti-TB</span> drug resistance (odds ratio (OR): 2.34, <i>P</i>=0.02), while the analyses for ethambutol resistance revealed an association with a rare A allele (rs2032582) (OR: 12.91, <i>P</i>=0.01), the haplotype TTC (OR: 5.83, <i>P</i>=0.05), and any haplotype containing the rare A allele (OR: 7.17, <i>P</i>=0.04).
|
28572401 |
2017 |
|
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Consistently, TT genotype of C1236T and TTT haplotype were also found more frequently in UC patients.
|
29543864 |
2018 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conversely, according to a recessive model, increased HCC risk was associated with two polymorphisms: <i>XRCC3</i> rs1799794 (OR = 3.70, 95%CI: 1.02-13.39, <i>P</i> = 0.0461) and <i>ABCB1</i> rs1128503 (OR = 2.06, 95%CI: 1.18-3.61, <i>P</i> = 0.0111).
|
29085212 |
2017 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from 30 pharmacogenomic studies that investigated MDR1 mRNA expression or gene variants (C3435T, G2677TA, C1236T) and response to therapy in acute myeloid leukaemia (AML) were synthesized.
|
23805980 |
2013 |
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Fifty-four Italian patients diagnosed with probable mild to moderate Alzheimer's disease, treated with donepezil (37 patients 5 mg/day, 17 patients 10 mg/day) were genotyped for CYP3A4 (*1B, *3, and *4), CYP3A5 (*2, *3, and *6) and ABCB1 (3435C>T, 2677G>T/A, and 1236C>T) polymorphisms.
|
20931330 |
2011 |
|
Crohn Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Five SNPs, rs1128503 (P = 0.02), rs1202184 (P = 0.008), rs1202186 (P = 0.02), rs2091766 (P = 0.03), and rs2235046 (P = 0.03) were nominally associated with noninflammatory CD.
|
19107781 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the first time, we demonstrated that MDR1 rs1128503 polymorphisms were associated with SLE susceptibility in Chinese Guangxi population.
|
28154898 |
2017 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
|
Bullous pemphigoid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.
|
29948283 |
2018 |
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated whether common MDR1 single nucleotide polymorphisms (SNPs) (C1236T, C3435T, and G2677T/A) affect predisposition to chronic lymphocytic leukemia (CLL).
|
21463115 |
2011 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C > T (rs1045642), 2677G > T/A (rs2032582), 1236C > T (rs1128503) and haplotypes were associated with AD risk.
|
27600024 |
2016 |