|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC (rs1234314, rs1234315) and AA (rs1600249, rs13277113) genotypes provided protective effects against AR, whereas the AG (rs13277113) genotype presented a risk factor for AR.
|
28713926 |
2017 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The C8orf13-BLK rs13277113 A and STAT4 rs7574865 T alleles had an additive effect on polymyositis/dermatomyositis susceptibility.
|
24632671 |
2014 |
|
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have analyzed for first time the implication of rs13277113 and rs2736340 variants from the C8orf13-BLK gene region in the susceptibility to GCA.
|
20156505 |
2010 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (P = 0.037, odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.62-0.99) and HT (P = 0.002, OR = 0.54, 95% CI = 0.36-0.81), compared to the controls.
|
30589937 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 x 10(-23)) and BLK (rs13277113, OR=0.77, P=1.34 x 10(-5)) with SLE.
|
19225526 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
In addition, we observed a genetic interaction between BLK (rs2736340T/C, rs13277113A/G) and BANK1 (R61H and A383T) associated with susceptibility to SLE.
|
31134304 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Minor alleles of rs13277113 (P = 4.2E-05, odds ratio [OR] 0.66, [95% CI 0.54-0.81]) and rs4840568 (P = 7.1E-05, OR 0.67, [95% CI 0.55-0.82]) were found to be protective against SLE.
|
22313735 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
On the assessment of available evidence, the authors concluded that moderate evidence exists for an association between the BLK rs13277113, rs2248932 variants and SLE.
|
21152986 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |