Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (P = 0.037, odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.62-0.99) and HT (P = 0.002, OR = 0.54, 95% CI = 0.36-0.81), compared to the controls.
|
30589937 |
2019 |
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC (rs1234314, rs1234315) and AA (rs1600249, rs13277113) genotypes provided protective effects against AR, whereas the AG (rs13277113) genotype presented a risk factor for AR.
|
28713926 |
2017 |
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the SNPs (rs2736340, rs13277113) of the FAM167A-BLK region, but not the BANK1 SNPs (rs4522865, rs17266594, and rs10516487), were associated with the development of pSS in Han Chinese.
|
23899688 |
2013 |
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have analyzed for first time the implication of rs13277113 and rs2736340 variants from the C8orf13-BLK gene region in the susceptibility to GCA.
|
20156505 |
2010 |
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
Polymyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The C8orf13-BLK rs13277113 A and STAT4 rs7574865 T alleles had an additive effect on polymyositis/dermatomyositis susceptibility.
|
24632671 |
2014 |
Polymyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism in C8orf13-BLK (dbSNP ID: rs13277113) was investigated in the Japanese population using a TaqMan assay in 283 polymyositis patients, 194 dermatomyositis patients, and 656 control subjects.
|
24632671 |
2014 |
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele frequencies for rs13277113 revealed an association restricted to the dcSSc subtype (P = 0.012, odds ratio [OR] 1.29) in the French sample.
|
21480188 |
2011 |
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The "A" allele at rs13277113 variant was associated with SSc in the U.S. series only (P = 3.6 x 10(-4), OR 1.32, 95% CI 1.1-1.6) and was significant in the combined analyses of the two series (P = 2.0 x 10(-3); OR 1.20, 95% CI 1.1-1.3).
|
19796918 |
2010 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our results indicated that the BLK rs13277113 polymorphism was involved in the genetic background of RA in Chinese population and the association of BANK1 rs3733197 polymorphism with RA was dependent on the genotype of BLK rs13277113 polymorphism, highlighting B-cell response implicated in the pathogenesis of RA.
|
28925718 |
2017 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In individuals carrying the BLK rs13277113 GG genotype, presence of the BANK1 rs3733197 G allele increased the risk of RA (odds ratio 1.21 [95% confidence interval 1.04-1.41], P = 0.015.
|
23646104 |
2013 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Mucocutaneous Lymph Node Syndrome
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies three new risk loci for Kawasaki disease.
|
22446962 |
2012 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
In addition, we observed a genetic interaction between BLK (rs2736340T/C, rs13277113A/G) and BANK1 (R61H and A383T) associated with susceptibility to SLE.
|
31134304 |
2019 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |