|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.
|
27778448 |
2017 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.
|
27778448 |
2017 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The FABP2 A54T missense mutation may contribute to the TG enrichment of HDL in the postprandial state that, in turn, may alter the risk of atherosclerotic vascular disease.
|
11707533 |
2001 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our findings suggest an involvement of the FABP2 (A54T) gene polymorphism in the pathogenesis of CVD.
|
15527447 |
2004 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to test the hypotheses that in MDD-patients the FABP2 Ala54Thr-polymorphism would be (I) more prevalent than in sex- and age-matched controls, (II) associated with observed alterations in FA-metabolism, and (III) associated with CVD-risk factor waist circumference.
|
24340071 |
2013 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that A54T polymorphism of the FABP2 gene is associated with cardiovascular disease risk in obese subjects.
|
17907115 |
2007 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of the present study was to investigate the role of ADMA and the FABP2 A54T polymorphism in carotid atherosclerosis.
|
17212611 |
2007 |
|
Carotid Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The FABP2 A54T polymorphism is not associated with severe carotid stenosis.
|
17212611 |
2007 |
|
Cerebral Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
No significant difference in Ala54Thr genotypic distribution of FABP2 was observed between stroke group (CI subgroup, CH subgroup included) and controls group.
|
25262933 |
2014 |
|
Cerebral Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals.
|
18506375 |
2008 |
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study shows that Ala54Thr of FABP2 may be not associated with stroke risk but associated with plasma TG level of stroke patients for Hunan Han population of China.
|
25262933 |
2014 |
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Parents of offspring with the T54T and T54A genotypes reported an increased prevalence of stroke compared to parents of offspring with the A54A genotype (P = 0.007).
|
10946885 |
2000 |
|
Cerebrovascular Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both asymmetric dimethylarginine (ADMA), which is an inhibitor of endothelial nitric oxide synthase and the fatty acid-binding protein 2 (FABP2) A54T gene polymorphism have been associated with cerebrovascular disease.
|
17212611 |
2007 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a stepwise forward selection procedure revealed that the 8733T-->C polymorphism of ALOX5AP (rs3803278), the C-->T (Ser532Leu) polymorphism of IRAK1 (rs1059703), and the 2445G-->A (Ala54Thr) polymorphism of FABP2 (rs1799883) were significantly (P<0.05) associated with the prevalence of CKD.
|
19288030 |
2009 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the complexity of the carcinogen for CRC, ADIPOQ rs2241766, UCP2 rs659366, FABP2 rs1799883 and red meat consumption potentially worked together in affecting CRC risk.
|
23826253 |
2013 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD.
|
9589253 |
1998 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 gene increases affinity of intestinal fatty acid-binding protein 2 for long-chain dietary fatty acids (FA) in subjects without diabetes.
|
20484485 |
2010 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results strongly suggest an association between the Ala54Thr polymorphism of FABP2 with diabetes, revealing a genetic dosage effect regarding its association with diabetes in Chilean elders.
|
17292994 |
2007 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 gene increases affinity of intestinal fatty acid-binding protein 2 for long-chain dietary fatty acids (FA) in subjects without diabetes.
|
20484485 |
2010 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results strongly suggest an association between the Ala54Thr polymorphism of FABP2 with diabetes, revealing a genetic dosage effect regarding its association with diabetes in Chilean elders.
|
17292994 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype in Ala54Thr polymorphism of FABP2 gene in patients with type 2 diabetes increased dietary FA absorption, and this might increase the susceptibility to the effects of dietary lipids.
|
20484485 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the T54 allele of FABP2 A54T is associated both with higher BMI and reduced risk of T2DM in women from the German EPIC-Potsdam study.
|
16718632 |
2006 |