|
Metabolic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects.
|
29338565 |
2018 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.
|
27778448 |
2017 |
|
Massive Osteolyses
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 was associated with high triglycerides levels, but not to GSD; suggesting that environmental factors modulate such susceptibility.
|
26019038 |
2016 |
|
Gerstmann-Straussler-Scheinker Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 was associated with high triglycerides levels, but not to GSD; suggesting that environmental factors modulate such susceptibility.
|
26019038 |
2016 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the complexity of the carcinogen for CRC, ADIPOQ rs2241766, UCP2 rs659366, FABP2 rs1799883 and red meat consumption potentially worked together in affecting CRC risk.
|
23826253 |
2013 |
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although Ala54Thr-polymorphism distribution was not associated with recurrent MDD, our results indicate that FABP2 may play a role in the explanation of observed FA-alterations in MDD.
|
24340071 |
2013 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study.
|
23826253 |
2013 |
|
Recurrent depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference.
|
24340071 |
2013 |
|
hearing impairment
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the Ala54Thr polymorphism of FABP2 was associated with a risk of hearing impairment in middle-aged and elderly people.
|
20202768 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the present study demonstrates that the polymorphism Ala54Thr of FABP in patients with NAFLD doesn't predict liver histological changes, nor both insulin resistance and serum adipokines variations.
|
19961041 |
2010 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a stepwise forward selection procedure revealed that the 8733T-->C polymorphism of ALOX5AP (rs3803278), the C-->T (Ser532Leu) polymorphism of IRAK1 (rs1059703), and the 2445G-->A (Ala54Thr) polymorphism of FABP2 (rs1799883) were significantly (P<0.05) associated with the prevalence of CKD.
|
19288030 |
2009 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent multivariable logistic regression analysis with adjustment for covariates revealed that the G-->A (Ser89Asn) polymorphism of UTS2 [odds ratio (OR), 1.90; 95% confidence interval (CI), 1.18-3.08], the 2445G-->A (Ala54Thr) polymorphism of FABP2 (OR, 1.72; 95% CI, 1.23-2.40), the -11377C-->G polymorphism of ADIPOQ (OR, 1.43; 95% CI, 1.15-1.79), the -231A-->G polymorphism of EDNRA (OR, 0.65; 95% CI, 0.48-0.89), and the -108/3G-->4G polymorphism of PDX1 (OR, 0.64; 95% CI, 0.48-0.87) were significantly (P<0.05) associated with MI.
|
19361803 |
2009 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of the present study was to investigate the role of ADMA and the FABP2 A54T polymorphism in carotid atherosclerosis.
|
17212611 |
2007 |
|
Carotid Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The FABP2 A54T polymorphism is not associated with severe carotid stenosis.
|
17212611 |
2007 |
|
Cerebrovascular Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both asymmetric dimethylarginine (ADMA), which is an inhibitor of endothelial nitric oxide synthase and the fatty acid-binding protein 2 (FABP2) A54T gene polymorphism have been associated with cerebrovascular disease.
|
17212611 |
2007 |
|
Insulin resistance syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia.
|
15547295 |
2005 |
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes.
|
16249461 |
2005 |
|
Familial hypercholesterolemia - heterozygous
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated Apo E (2, 3, 4), MTP (-493G/T), Apo B (-516C/T), Apo A-V (-1131T/C), HL (-514C/T and -250G/A), FABP-2 (A54T), LPL (D9N, N291S, S447X) and ABCA1 (R219K) polymorphisms in 221 unrelated FH index cases and 349 FH relatives with defined LDL-R gene mutations.
|
15135251 |
2004 |
|
Hyperlipidemia, Familial Combined
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, we have evaluated the association of the common variants in the lipoprotein lipase (LPL) (D9N, N291S, and S447X), insulin receptor substrate-1 (IRS-1) (G972R), fatty acid binding protein-2 (FABP-2) (A54T), and beta3-adrenergic receptor (beta3-AR) (W64R) genes with lipid and lipoprotein levels in 30 Italian FCHL families (195 individuals).
|
12370850 |
2002 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that the Ala54Thr substitution in the FABP2 gene is associated with increased fat oxidation and hyperinsulinemia in normal Korean men, but these effects are not mediated by an increase in the intestinal fatty acid absorption.
|
11288045 |
2001 |
|
Obesity, Morbid
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate whether the Ala54Thr polymorphism of the fatty acid binding protein 2 gene is associated with obesity and obesity with dyslipidemia in Japanese schoolchildren, we analyzed 370 children with morbid obesity and 463 control children of normal weight.
|
11866034 |
2001 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD.
|
9589253 |
1998 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.
|
27778448 |
2017 |