|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
|
30916218 |
2019 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525), and TNFR1 -609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients.
|
29404828 |
2018 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
A long-term observational early RA inception cohort (n = 208) with detailed information about disease activity and radiologic damage after 3, 6 and 9 years of disease was genotyped for the TNFA -308G > A promoter polymorphism (rs1800629).
|
23217265 |
2012 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our results show that TNFA rs1800629 gene polymorphism is associated with predisposition to CV complications in patients with RA.
|
21420089 |
2011 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA.
|
22927710 |
2012 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study identifies a potentially important role for TNF-α rs1800629 polymorphisms in the susceptibility to RA.However, further studies in larger cohorts are required.
|
25263964 |
2014 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
TNF-α rs1800629 A/G, NLRP1 rs878329 C/G and NLRP1 rs6502867 C/T polymorphisms were not associated with risk of RA or AS.
|
24065540 |
2013 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253 A>G) and tumor necrosis factor (TNF -308A, rs1800629 G>A), form the G-A haplotype repeatedly associated with increased risk of non-Hodgkin lymphoma (NHL) in individuals uninfected with HIV-1.
|
19654554 |
2009 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma.
|
22649007 |
2012 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms in immunoregulatory genes (TNF G308A, rs1800629 and IL10 T3575A, rs1800890) have been recently reported as risk factors for non-Hodgkin lymphoma (NHL) in a large pooled analysis.
|
17510437 |
2007 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53).
|
25713336 |
2015 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
Compared with the wild-type (GG), the AA genotype for the TNF promoter polymorphism G-308A (rs1800629) was associated with increased risk of NHL [odds ratio (OR), 2.14; 95% confidence interval (95% CI), 0.94-4.85], whereas the GA genotype was not (OR, 1.00; 95% CI, 0.74-1.34).
|
18990758 |
2008 |
|
Lymphoma, Non-Hodgkin
|
|
0.060 |
GeneticVariation
|
BEFREE |
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87).
|
20087644 |
2010 |
|
Septicemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)).
|
18434886 |
2008 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
The TNFA-308G/A (rs1800629) and -238G/A (rs361525) polymorphisms are two widely investigated variants for their associations with risk of cervical cancer, but the results are conflicting.
|
21670964 |
2012 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-?) promoter region at positions -308G>A (rs1800629) and -238G>A (rs361525) to cervical cancer risk have been inconclusive.
|
27039819 |
2016 |
|
Septicemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population.
|
29340067 |
2017 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer.
|
29940817 |
2018 |
|
Septicemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
The TNFA-308G/A (rs1800629) and -238G/A (rs361525) polymorphisms are two widely investigated variants for their associations with risk of cervical cancer, but the results are conflicting.
|
21670964 |
2012 |
|
Septicemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The minor allele frequency of rs1800629 was significantly higher in severe sepsis patients than that in both healthy controls (P(adj) = 0.00046, odds ratio (OR)(adj) = 1.92) and sepsis patients (P(adj) = 0.002, OR(adj) = 1.56).
|
23029405 |
2012 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
There are no significant relationship between rs1800629 polymorphism and high risk HPV infection (OR = 0.649, 95% CI: 0.253-1.670, P = 0.371), cervical cancer (OR = 0.993, 95% CI: 0.376-2.618, P = 0.988), or cervical cancer with HPV infection (OR = 0.663, 95% CI: 0.250-1.758, P = 0.409).
|
23028877 |
2012 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
Using high-resolution melting curve analysis, we investigated the prevalence of the TNF-α -308 G/A transition (rs1800629) in patients with cervical cancer (n = 362) and control subjects (n = 399).
|
25614219 |
2015 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The TNFA-308G/A (rs1800629) and -238G/A (rs361525) polymorphisms are two widely investigated variants for their associations with risk of cervical cancer, but the results are conflicting.
|
21670964 |
2012 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer.
|
29940817 |
2018 |