|
Human papilloma virus infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study aims to find out the impact of IL-10 promoter polymorphisms at -1082A/G (rs1800896), -819C/T (rs1800872), and -592C/A (rs1800871) sites along with IL-10 production and HPV infection in the progression of cervical cancer.
|
25412954 |
2015 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent.
|
27558476 |
2016 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.
|
25280384 |
2014 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subsequent combined analysis of the Malay and Chinese revealed significant association of rs1800871 with all (ALL) NHL subtypes (pMeta-ALL-NHL-Rec = 0.001), ALL B-cell subtypes (pMeta-ALL-B-cell-Rec = 0.003), diffuse large B-cell lymphoma (DLBCL) subtype (pMeta-DLBCL-Rec = 0.002) and ALL T-cell subtypes (pMeta-ALL-T-cell-Rec = 0.031).
|
24684230 |
2015 |
|
Lymphoma, Non-Hodgkin
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriage of at least one copy of the T allele for the IL10 rs1800871 (as compared to no copies) was associated with decreased AIDS-NHL risk specific to lymphomas arising from the CNS (CC vs. CT/TT: OR = 0.3; 95% CI 0.1, 0.7) but not systemically (CC vs. CT/TT: OR = 1.0; 95% CI 0.5, 1.9) (Pheterogeneity = 0.03).
|
20299965 |
2010 |
|
Irritable Bowel Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no significant associations are found between rs1800871 and IBS risk.
|
24409078 |
2013 |
|
Human papilloma virus infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
The allelic and genotypic distribution of IL10-819 (rs1800871) and IL10-1082 (rs1800896) and HPV infection (HPVs 58, 18 and 31) has showed no statistically significant differences between case and control groups for the assessed IL10 polymorphisms.
|
29935877 |
2019 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study aims to find out the impact of IL-10 promoter polymorphisms at -1082A/G (rs1800896), -819C/T (rs1800872), and -592C/A (rs1800871) sites along with IL-10 production and HPV infection in the progression of cervical cancer.
|
25412954 |
2015 |
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
|
27002767 |
2016 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD).
|
26505399 |
2015 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present case-control study inspected the association between seven single nucleotide polymorphisms (SNPs) of IL4 (IL4<sub>-1098</sub>: rs2243248, IL4<sub>-590</sub>: rs2243250, and IL4<sub>-33</sub>: rs2070874), IL4RA (IL4RA<sub>+1902</sub>: rs1801275), and IL10 (IL10<sub>-1082</sub>: rs1800896, IL10<sub>-819</sub>: rs1800871, and IL10<sub>-592</sub>: rs1800872) genes and MS in Iraqi patients.
|
31264107 |
2019 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population.
|
27525910 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, genotyping results demonstrated that subjects carrying both the rs1800871 C allele and rs1800872 G allele had a moderately increased risk of AML, indicating that the 2 genotypes had a synergistic effect on AML risk (odds ratio = 2.03, 95% confidence interval = 1.24- 3.15).
|
25730030 |
2015 |
|
Esophageal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
|
27002767 |
2016 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
As for complications in DM, significant association with the risk of diabetic nephropathy (DN) was detected for the rs1800871 polymorphism.
|
30223288 |
2018 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian.
|
29734056 |
2018 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To further investigate the proposed association and to clarify the role of cytokines as a potential cause for AD susceptibility, we analyzed genotypes, allele distributions and haplotypes of IL10 promoter polymorphisms -1082 (rs1800896) and -819 (rs1800871) in an Italian sample of 222 sporadic AD patients and 179 normal controls.
|
17420099 |
2007 |
|
Malignant neoplasm of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
|
27002767 |
2016 |
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
We determined whether single nucleotide polymorphisms (SNPs) at positions -1082 A/G (rs1800870), -819 T/C (rs1800871) and -592 A/C (rs1800872) in the IL-10 gene promoter were involved in predisposing an individual to oral cancer.
|
17980158 |
2008 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based upon the functional role of the TNF-α [-308 G(low) → A(high) (rs1800629)] and IL-10 [-1082 A(low) → G(high) (rs1800870), -819 T(low) → C(high) (rs1800871) and -592 A(low) → C(high) (rs1800872)] single nucleotide polymorphisms (SNPs) on production levels, we genotyped 76 patients with pulmonary tuberculosis (TB) (pTB), 55 patients with extrapulmonary TB (epTB) and 95 healthy blood donors by polymerase chain reaction fragment length polymorphism (PCR-RFLP).
|
21609779 |
2011 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers.
|
20112337 |
2010 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cox proportional hazards analyses demonstrated that the genotype TT of IL10 rs1800871 and AA plus AC of rs1800872 were predictive of longer PFS and event-free survival (EFS) in DLBCL patients treated with R-CHOP.
|
27822610 |
2017 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To further investigate the proposed association and to clarify the role of cytokines as a potential cause for AD susceptibility, we analyzed genotypes, allele distributions and haplotypes of IL-10 promoter polymorphisms -1082 (rs1800896) and -819 (rs1800871) in a Mexican population: 986 normal controls and 221 cases divided as follows: 122 with Alzheimer disease (AD), 67 with (VaD) and 32 with mixed dementia (AD/VaD).
|
27474414 |
2016 |
|
Malignant neoplasm of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
|
27002767 |
2016 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, our results demonstrated that rs1800896, rs1800871 and rs1800872 polymorphisms may not be the risk factor for the development of MS in both the populations.
|
28385181 |
2017 |