|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
In a Dutch case-control study comprising 123 cases with coronary heart disease (CHD) and 540 controls, we evaluated whether the MTR 2756A>G polymorphism was associated with plasma homocysteine, vitamin B12, folate concentrations, and CHD risk.
|
12893022 |
2003 |
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
|
12893022 |
2003 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
|
12893022 |
2003 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Contradictory findings have been recently published on the evaluation of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677 C-->T) and methionine synthase reductase (MTRR 66 A-->G) as risk factors for having a child with Down syndrome (DS); however, the influence of polymorphisms of methionine synthase (MTR 2756 A-->G) and of MTHFR 1298 A-->C has never been evaluated.
|
12923861 |
2003 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Contradictory findings have been recently published on the evaluation of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677 C-->T) and methionine synthase reductase (MTRR 66 A-->G) as risk factors for having a child with Down syndrome (DS); however, the influence of polymorphisms of methionine synthase (MTR 2756 A-->G) and of MTHFR 1298 A-->C has never been evaluated.
|
12923861 |
2003 |
|
Adenoma of large intestine
|
|
0.050 |
GeneticVariation
|
BEFREE |
Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk.
|
14744749 |
2004 |
|
Vitamin B 12 Deficiency
|
|
0.020 |
GeneticVariation
|
BEFREE |
Finally, folate fortification unveiled cobalamin deficiency in some patients, associated with the methionine synthase A2756G mutation.
|
15063399 |
2004 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated joint effects of polymorphisms of the MTHFR (677 C-->T, 1298A-->C) and MS genes (2756 A-->G), dietary folate intake and cigarette smoking on the risk of bladder cancer in a case-control study.
|
15117811 |
2004 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated joint effects of polymorphisms of the MTHFR (677 C-->T, 1298A-->C) and MS genes (2756 A-->G), dietary folate intake and cigarette smoking on the risk of bladder cancer in a case-control study.
|
15117811 |
2004 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated joint effects of polymorphisms of the MTHFR (677 C-->T, 1298A-->C) and MS genes (2756 A-->G), dietary folate intake and cigarette smoking on the risk of bladder cancer in a case-control study.
|
15117811 |
2004 |
|
Primary central nervous system lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.
|
15138479 |
2004 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).
|
15159311 |
2004 |
|
Lymphoma, Non-Hodgkin
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).
|
15159311 |
2004 |
|
Lymphoma, Non-Hodgkin
|
|
0.040 |
GeneticVariation
|
BEFREE |
The polymorphisms examined and haplotypes generated included thymidylate synthase (TYMS 28-bp triple repeat [3R]-->double repeat [2R], 1494del6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the largest and most comprehensive to date to evaluate associations between genetic polymorphisms in folatemetabolizing genes and NHL risk.
|
15198953 |
2004 |
|
Alzheimer's Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The association of occurrence and dementia severity (Reisberg score <6 and >or=6) of Alzheimer's disease with APO-E, IL-1A, IL-1B, IL-1RN, MTHFR677 C-->T and 1298A-->C, MTR 2756 A-->G, and TC 776 C-->G polymorphisms was evaluated by multivariate logistic regression analysis after adjustment for age, sex, and age of onset of Alzheimer's disease.
|
15201366 |
2004 |
|
Presenile dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of occurrence and dementia severity (Reisberg score <6 and >or=6) of Alzheimer's disease with APO-E, IL-1A, IL-1B, IL-1RN, MTHFR677 C-->T and 1298A-->C, MTR 2756 A-->G, and TC 776 C-->G polymorphisms was evaluated by multivariate logistic regression analysis after adjustment for age, sex, and age of onset of Alzheimer's disease.
|
15201366 |
2004 |
|
Dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of occurrence and dementia severity (Reisberg score <6 and >or=6) of Alzheimer's disease with APO-E, IL-1A, IL-1B, IL-1RN, MTHFR677 C-->T and 1298A-->C, MTR 2756 A-->G, and TC 776 C-->G polymorphisms was evaluated by multivariate logistic regression analysis after adjustment for age, sex, and age of onset of Alzheimer's disease.
|
15201366 |
2004 |
|
Lymphoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes.
|
15551285 |
2004 |
|
Childhood Lymphoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes.
|
15551285 |
2004 |
|
Adult Lymphoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes.
|
15551285 |
2004 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, the MTHFR C677T and A1298C and the MS A2756G polymorphisms were not associated with an increased risk of uterine cervical cancer.
|
15589597 |
2005 |
|
Colorectal Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We evaluated the relation between the polymorphisms 677C --> T of the methylenetetrahydrofolate reductase (MTHFR) and 2756A --> G of the methionine synthase (MTR) genes and risk of colorectal cancer.
|
15598777 |
2004 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
We evaluated the relation between the polymorphisms 677C --> T of the methylenetetrahydrofolate reductase (MTHFR) and 2756A --> G of the methionine synthase (MTR) genes and risk of colorectal cancer.
|
15598777 |
2004 |
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |