Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk.
|
15790587 |
2005 |
Esophageal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk.
|
15790587 |
2005 |
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk.
|
15790587 |
2005 |
Myocardial Infarction
|
|
0.050 |
GeneticVariation
|
BEFREE |
We examined whether C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms could affect the relative risk for MI.
|
15820491 |
2005 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we determined polymorphisms of MTHFR A222V (677C > T), MTHFR E429A (1298A > C), MTRR I22M (66A > G), MTR D919G (2756A > G), and CBS 844ins68 and total plasma homocysteine levels (tHcy) among 154 mothers of children with Down syndrome (DS) and 158 control mothers from Brazil.
|
15889417 |
2005 |
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we determined polymorphisms of MTHFR A222V (677C > T), MTHFR E429A (1298A > C), MTRR I22M (66A > G), MTR D919G (2756A > G), and CBS 844ins68 and total plasma homocysteine levels (tHcy) among 154 mothers of children with Down syndrome (DS) and 158 control mothers from Brazil.
|
15889417 |
2005 |
Squamous cell carcinoma of the head and neck
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide evidence that support the association between the MTR A2756G and MTRR G66A polymorphisms and SCCHN risk and that these two polymorphisms may have a joint effect on risk of SCCHN.
|
15894670 |
2005 |
Neural Tube Defects
|
|
0.090 |
GeneticVariation
|
BEFREE |
No significant NTD association was found with S175L or K350R in cases or their parents and no interactions were observed between these polymorphisms and the D919G variant of MTR or the A222V variant of 5,10-methylenetetrahydrofolate reductase (MTHFR).
|
15979034 |
2005 |
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide evidence supporting the association between the MTR 2756A>G and MTRR 66A>G polymorphisms and lung cancer risk, which may be modulated by dietary nutrient intake.
|
16006998 |
2005 |
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide evidence supporting the association between the MTR 2756A>G and MTRR 66A>G polymorphisms and lung cancer risk, which may be modulated by dietary nutrient intake.
|
16006998 |
2005 |
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide evidence supporting the association between the MTR 2756A>G and MTRR 66A>G polymorphisms and lung cancer risk, which may be modulated by dietary nutrient intake.
|
16006998 |
2005 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of the present study was to analyse these findings among the French population and to investigate whether common polymorphisms in genes of the folate and homocysteine pathway, including the MTHFR 677C > T, MTHFR 1298A > C, the methionine synthase (MTR) 2756A > G, the cystathionine beta-synthase (CBS) 844Ins68 and the reduced folate carrier (RFC-1) 80G > A polymorphisms, contribute to the risk of trisomy 21.
|
16115349 |
2005 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
In contrast, the association of the substitutions A2756G of methionine synthase (MTR), A66G of methionine synthase reductase (MTRR) and C776G of transcobalamin (TCN) to both t-Hcys and CAD needs to be evaluated further.
|
16268464 |
2005 |
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither MTR D919G nor RFC 80G>A polymorphisms were associated with altered colon cancer risk.
|
16284371 |
2005 |
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither MTR D919G nor RFC 80G>A polymorphisms were associated with altered colon cancer risk.
|
16284371 |
2005 |
Squamous cell carcinoma of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma.
|
16333305 |
2006 |
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, pretherapeutic determination of the MTR A2756G polymorphism may predict survival of multimodally treated oesophageal squamous cell carcinomas.
|
16333305 |
2006 |
Sudden sensorineural hearing loss
|
|
0.020 |
GeneticVariation
|
BEFREE |
The allelic frequency of the G allele of the MTR A2756G polymorphism among SSNHL patients (12.5%) was also significantly higher than in the control group (5%) (p = 0.033).
|
16778415 |
2006 |
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methionine-synthase-reductase A66G, the methionine-synthase A2756G and the cystathionine-beta-synthase 844ins68 polymorphisms were not associated with increased risk of Down syndrome.
|
16845273 |
2006 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methionine-synthase-reductase A66G, the methionine-synthase A2756G and the cystathionine-beta-synthase 844ins68 polymorphisms were not associated with increased risk of Down syndrome.
|
16845273 |
2006 |
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
By analysis of a large number of subjects and a more specific patient selection, we showed the first genetic evidence that MTHFR C677T, MS A2756G and MTRR A66G genotypes were independently associated with male infertility.
|
16861746 |
2006 |
Cerebrovascular Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.
|
16894458 |
2006 |
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme.
|
17119065 |
2006 |
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme.
|
17119065 |
2006 |