|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphism in rs10865710, rs1805192 and rs4646903 and interaction between rs1805192 and rs4646903 were related with increased CAD susceptibility.
|
28415751 |
2017 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.
|
17563457 |
2007 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala PPAR γ2 gene polymorphism in PCOS women: the role of compounds regulating satiety.
|
21827375 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The data suggest a contribution of the Pro12Ala polymorphism of PPARgamma to genetic susceptibility to type 2 diabetes mellitus and hypertension, but not to insulin sensitivity in hypertensive subjects.
|
15563983 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The alanine variant of the Pro12Ala polymorphism of PPARgamma might be associated with decreased risk of DR in T2DM.
|
18077048 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore assessed the associations between the most common variant of the PPAR-gamma, the Pro12Ala (P12A) substitution in the PPAR-gamma 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D).
|
12406034 |
2002 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.
|
17941898 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of P12A polymorphism was 0.16 and the t allele of c1431t polymorphism, 0.13 in patients with type 2 diabetes, and 0.13 and 0.12 respectively in subjects without diabetes 3.2% of patients with and 1.4% without type 2 diabetes were A12A.
|
11409297 |
2001 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were significant associations of the Pro12Ala single nucleotide polymorphism (SNP) genotypes with diabetes in both case-control comparisons (P=0.025 and P=0.039).
|
16401314 |
2005 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals.
|
17898990 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus.
|
12218380 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the PPARG gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced fluid retention and edema in patients with type 2 diabetes.
|
16822823 |
2006 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain.
|
12370112 |
2002 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat.
|
16777151 |
2006 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 microg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 microg/ml, P = 0.622).
|
17335469 |
2007 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
|
21795447 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
|
17213274 |
2007 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
17763950 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find any significant association between three SNPs in the PGC-1alpha gene and T2DM in Hispanics or NHW; however, using FBAT, we found the common Thr612Thr allele of the PGC-1alpha gene to be associated with T2DM among Hispanic subjects carrying the rare Pro12Ala allele of the PPAR-gamma gene (p=.003).
|
17479445 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression analysis showed that Pro12Ala polymorphism was an independent determinant of type 2 diabetes in this population.
|
17439324 |
2007 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism.
|
16489531 |
2006 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results demonstrated that the PPARγ2 Pro12Ala polymorphism might be risk-conferring locus for the progression of CAD among Caucasians, but not among Asians.
|
23300871 |
2012 |