BODY MASS INDEX, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
OBESITY, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
DIABETES MELLITUS, NONINSULIN-DEPENDENT, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
INTIMAL MEDIAL THICKNESS OF INTERNAL CAROTID ARTERY, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype.
|
9918859 |
1999 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the study was carried out on a sufficiently large sample, the conclusions do not support a major role for the Pro12Ala substitution of the PPAR-gamma gene in the etiology of type 2 diabetes.
|
10389855 |
1999 |
Hyperinsulinism
|
|
0.090 |
GeneticVariation
|
BEFREE |
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.
|
10382597 |
1999 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro</span>12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the PPARgamma is a thrifty gene and that the Pro12Ala PPARgamma2 polymorphism protects against type 2 diabetes in the Japanese.
|
10777704 |
2000 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9.
|
10873398 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We were able to confirm only one association, that of the common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma(PPARgamma) with type 2 diabetes.
|
10973253 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the Taiwanese, the Pro12Ala PPARgamma2 gene variant may contribute to fat accumulation and a higher BMI independent of type 2 diabetes.
|
11079814 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree.
|
10843190 |
2000 |
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05).
|
10843155 |
2000 |
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of P12A polymorphism was 0.16 and the t allele of c1431t polymorphism, 0.13 in patients with type 2 diabetes, and 0.13 and 0.12 respectively in subjects without diabetes 3.2% of patients with and 1.4% without type 2 diabetes were A12A.
|
11409297 |
2001 |
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis.
|
11684868 |
2001 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
|
11289058 |
2001 |