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MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1(finding)
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0.700 |
SusceptibilityMutation
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CLINVAR |
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Behcet Syndrome
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0.010 |
GeneticVariation
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BEFREE |
All patients with BD and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for +936 C/T (rs3025039) and -634 C/G (rs2010963) mutations and for an 18 base pair (bp) insertion/deletion (I/D) polymorphism at -2549 of the the VEGF promoter region.
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15338501 |
2004 |
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Rheumatoid Arthritis
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0.040 |
GeneticVariation
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BEFREE |
The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA).
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16216669 |
2005 |
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Giant Cell Arteritis
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0.010 |
GeneticVariation
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BEFREE |
We wanted to assess the potential role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants in GCA susceptibility and clinical ischemic complications.
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16142870 |
2005 |
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Henoch-Schoenlein Purpura
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0.010 |
GeneticVariation
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BEFREE |
We investigated the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants in the susceptibility to HSP, to identify associations with severe systemic complications of HSP, in particular with renal complications.
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16395752 |
2006 |
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Mucocutaneous Lymph Node Syndrome
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0.010 |
GeneticVariation
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BEFREE |
The haplotype CGCC (based on rs699947, rs2010963, rs25648, and rs3025039) was significantly associated with the development of KD (hap score 3.8; P = 0.0002).
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16645995 |
2006 |
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Age related macular degeneration
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0.050 |
GeneticVariation
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BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
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19761764 |
2009 |
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Congenital heart disease
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0.010 |
GeneticVariation
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BEFREE |
We evaluated the association of VEGFA polymorphisms c.-2578C>A (rs699947), c.-1154G>A (rs1570360) and c.-634C>G (rs2010963) with congenital heart disease in Chilean patients with microdeletion 22q11.
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20140301 |
2009 |
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Acute myocardial infarction
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0.010 |
GeneticVariation
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BEFREE |
Three VEGF gene single nucleotide polymorphisms (SNPs) (-2578A>C rs699947, -634C>G rs2010963 and +936C>T rs3025039) were genotyped in 516 control subjects of the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort and in 251 survivors of AMI.
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19089753 |
2009 |
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Coronary Artery Disease
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0.060 |
GeneticVariation
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BEFREE |
This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD).
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20621071 |
2010 |
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Coronary Arteriosclerosis
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0.030 |
GeneticVariation
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BEFREE |
We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis.
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20489684 |
2010 |
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Rheumatoid Arthritis
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0.040 |
GeneticVariation
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BEFREE |
No significant association between the VEGFA rs2010963 and the rs1570360 polymorphisms (neither isolated nor joined as allelic combinations) with clinically evident CV disease was found in this series of patients with RA.
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21388351 |
2011 |
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Rheumatoid Arthritis
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0.040 |
GeneticVariation
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BEFREE |
Our data suggested a trend of association between VEGF gene polymorphisms and RA, and patients who carried the haplotype GA of rs2010963 and rs833070 were more susceptible to RA.
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21245770 |
2011 |
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Glioma
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0.030 |
GeneticVariation
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BEFREE |
In the single-locus analysis, we found that rs2010963 (G+405C, G-634C) [odds ratio (OR) = 1.29; 95% confidence interval (CI) = 1.04-1.58; GC/CC vs. GG] and rs3025030 (OR = 2.21; 95% CI = 1.18-4.14; CC vs. GG/GC) were associated with increased risk for glioma, and rs3024994 (OR = 0.66; 95% CI = 0.47-0.94; CT/TT vs. CC) was associated with reduced glioma risk, albeit insignificant after Bonferroni correction for multiple comparisons.
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20209496 |
2011 |
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Age related macular degeneration
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0.050 |
GeneticVariation
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BEFREE |
The present meta-analyses indicated that there were no significantly associations between VEGF polymorphisms (rs833061, rs1413711, rs2010963) and the risk of AMD, although the association was different for each polymorphism among different populations.
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22307787 |
2012 |
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Malignant neoplasm of mouth
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0.010 |
GeneticVariation
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BEFREE |
In this study, we examined whether individual polymorphisms within VEGF-A gene, rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (-634G/C), rs3025039 (+936C/T) or their haplotypes are associated with an oral cancer risk and survival.
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22818823 |
2012 |
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Migraine Disorders
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0.010 |
GeneticVariation
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BEFREE |
This study aimed at characterizing interactions among nine clinically relevant polymorphisms in eNOS (T(-786)C/rs2070744, the 27 bp VNTR in intron 4, the Glu298Asp/rs1799983, and two additional tagSNPs rs3918226 and rs743506), iNOS (C(-1026)A/rs2779249 and G2087A/rs2297518), and VEGF (C(-2578)A/rs699947 and G(-634)C/rs2010963) in migraine patients and control group.
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22865486 |
2012 |
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Multiple Myeloma
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0.010 |
GeneticVariation
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BEFREE |
Retrospectively, the SNPs -2,578C>A (rs699947), -460C>T (rs833061), +405G>C (rs2010963) and +936C>T (rs3025039) in the VEGF gene were examined in 348 patients with newly diagnosed multiple myeloma initially treated with HDT, where 176 patients were treated with thalidomide at relapse.
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22139971 |
2012 |
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Myopia
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0.010 |
GeneticVariation
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BEFREE |
This association was successfully replicated in the additional 76 eyes with myopic CNV, and pooled analysis revealed significant association of rs2010963 with CNV size (P = 0.00078).
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22427559 |
2012 |
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Lip and Oral Cavity Carcinoma
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0.010 |
GeneticVariation
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BEFREE |
In this study, we examined whether individual polymorphisms within VEGF-A gene, rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (-634G/C), rs3025039 (+936C/T) or their haplotypes are associated with an oral cancer risk and survival.
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22818823 |
2012 |
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Pneumonitis
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0.010 |
GeneticVariation
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BEFREE |
We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and +936 C > T [rs3025039]) and estimated the associations of their genotypes and haplotypes with severe radiation pneumonitis (RP ≥grade 3) in 195 NSCLC patients.
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22320189 |
2012 |
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Coronary Artery Disease
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0.060 |
GeneticVariation
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BEFREE |
The possible association of rs699947 and rs2010963 with CAD risks warrant confirmation in independent case-control studies and may be informative for future investigations on the pathogenesis of CAD.
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23545315 |
2013 |
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Coronary Artery Disease
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0.060 |
GeneticVariation
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BEFREE |
Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.
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23880405 |
2013 |
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Age related macular degeneration
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0.050 |
GeneticVariation
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BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
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23761723 |
2013 |
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Rheumatoid Arthritis
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0.040 |
GeneticVariation
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BEFREE |
VEGFA rs699947 C/A, rs2010963 G/C, and rs3025039 C/T polymorphisms were not associated with the risk of RA.
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23848209 |
2013 |