rs2596542, MICA-AS1;MICA

N. diseases: 18
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. 30723271 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC. 30882647 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Nevertheless, we also detected significant associations between rs2596542G>A and HCV-induced HCC. 30967497 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC. 31419949 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039). 31471884 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection. 31471884 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC. 29584564 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample. 29584564 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC. 29731972 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. 27998720 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients. 28417047 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma. 28427234 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC). 28928439 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150). 26517016 2016
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC. 26893439 2016
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively. 24357186 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542. 23593449 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population. 23665287 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population. 23994040 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). 23024757 2012
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
HIV-1, RESISTANCE TO
CUI: C1836231
Disease: HIV-1, RESISTANCE TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009