rs2596542, MICA;MICA-AS1

N. diseases: 10
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma. 28427234 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86-26.38·61, P=0·002) and the MICA rs2596542 A allele (HR/CI: 4·37/1·52-12·07, P=0·002) were independently associated with HCC development. 27998720 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150). 26517016 2016
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC. 26893439 2016
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC. 23994040 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population. 23665287 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). 23024757 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation BEFREE Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542. 23593449 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.880 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
HIV-1 infection
CUI: C2363741
Disease: HIV-1 infection
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2010
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.040 GeneticVariation BEFREE A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population. 23994040 2014
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.040 GeneticVariation BEFREE Recently, genetic variations in MICA (lead single nucleotide polymorphism [SNP] rs2596542) were identified by a genome-wide association study (GWAS) to be associated with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) in Japanese patients. 23665287 2014
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.040 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population. 24204805 2014
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.040 GeneticVariation BEFREE We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). 23024757 2013
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.010 GeneticVariation BEFREE Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection. 26517016 2016
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.010 GeneticVariation BEFREE Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC. 23994040 2014
Hepatitis B Virus-Related Hepatocellular Carcinoma
0.010 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population. 24204805 2014
Liver Cirrhosis
CUI: C0023890
Disease: Liver Cirrhosis
0.010 GeneticVariation BEFREE Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC. 23994040 2014
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.010 GeneticVariation BEFREE Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients. 23994040 2014
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.010 GeneticVariation BEFREE These findings indicate that the MICA rs2596542 has a significant role in HBV infection. 23994040 2014
Virus Diseases
CUI: C0042769
Disease: Virus Diseases
0.010 GeneticVariation BEFREE Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients. 23994040 2014