|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report.
|
21402545 |
2011 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations.
|
22105689 |
2012 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
In addition, HLA-DP rs3077 showed an approaching significant effect on susceptibility to HBV persistent infection and HCC development when considering multiple testing adjustments.
|
22105689 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians.
|
22448225 |
2012 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6-11.1; p = 0.31).
|
22448225 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of meta-analysis pooling all eligible studies also showed that rs3077-A and rs9277535-A alleles were associated with an increased clearance rate to HBV infection (rs3077: OR=0.57, 95% CI=0.44-0.75; rs9277535: OR=0.56, 95% CI=0.47-0.63).
|
22543033 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |