|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population.
|
29467950 |
2018 |
|
Vasculitis of the skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs3077 AA genotype carriers showed lower concentration of inflammatory cytokines and lower cutaneous vasculitis incidence than did the other two genotype.
|
28094303 |
2017 |
|
Occult chronic type B viral hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele in rs3077 was significantly correlated with OBI [odds ratio (OR) = 3.87, 95% confidence interval (CI) = 1.58-9.49, p = 0.0015].
|
29061159 |
2017 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that rs3077 significantly increased the risk of chronic HCV infection in additive models and dominant models (odds ratio (OR) = 1.32 and 1.53).
|
24897020 |
2014 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001).
|
24465836 |
2014 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
There was no significant association between HLA-DP polymorphism (rs3077) and IFN-γ receptor-2 gene polymorphism (rs2284553) with viral activity in HBeAg-negative CHB patients.
|
23980639 |
2014 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6-11.1; p = 0.31).
|
22448225 |
2012 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our analysis indicated a significant</span> association of rs3077 and rs9277535 with HCC susceptibility, suggesting that rs3077 might act beneficially against HCC susceptibility (A vs G: OR = 0.884, 95%CI = 0.803-0.973, P = 0.012; GA vs GG: OR = 0.842, 95%CI = 0.733-0.967, P = 0.015; AA+GA vs GG: OR = 0.848, 95%CI = 0.744-0.968, P = 0.014), and that rs9277535 might promote HCC susceptibility (AA vs GA: OR = 1.202, 95%CI = 1.011-1.428, P = 0.037).
|
26634522 |
2015 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27).
|
25365208 |
2014 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
In addition, HLA-DP rs3077 showed an approaching significant effect on susceptibility to HBV persistent infection and HCC development when considering multiple testing adjustments.
|
22105689 |
2012 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |