|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians.
|
22448225 |
2012 |
|
Vasculitis of the skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs3077 AA genotype carriers showed lower concentration of inflammatory cytokines and lower cutaneous vasculitis incidence than did the other two genotype.
|
28094303 |
2017 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs3077 and rs2284553 polymorphisms were not associated with HBV viral load in terms of allelic frequency, genotypic frequency, dominant/recessive gene action. rs9808753 (G allele) was associated with a reduced chance of "undetectable HBV DNA" for patients below the age of 50 years in allelic frequency analysis (odds ratio 0.562; 95% confidence interval, 0.326-0.967; P value = 0.037).
|
23980639 |
2014 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report.
|
21402545 |
2011 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese.
|
23825586 |
2013 |
|
Complete atrioventricular block
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6-11.1; p = 0.31).
|
22448225 |
2012 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27).
|
25365208 |
2014 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
In addition, HLA-DP rs3077 showed an approaching significant effect on susceptibility to HBV persistent infection and HCC development when considering multiple testing adjustments.
|
22105689 |
2012 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |