|
Adenocarcinoma of lung (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that FGFR4 Gly388Arg polymorphism may predict prognosis in lung adenocarcinoma.
|
16061909 |
2005 |
|
Adenocarcinoma of lung (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings confirm the significant association of the FGFR4 Gly388Arg polymorphism with clinical stage and overall survival in an Italian lung ADCA population and demonstrate a FGFR4 genotype-dependent transcriptional profile present in normal lung tissue.
|
19296538 |
2009 |
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that the FGFR4 Arg allele of the Gly388Arg polymorphism and the G allele of the rs2011077 polymorphism have a significant impact on the development of prostate cancer and BPH, and the progression of prostate cancer in a Japanese population.
|
18756523 |
2008 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown.
|
17088904 |
2006 |
|
Body Fat Distribution
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
|
30664634 |
2019 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
G388R mutation of the FGFR4 gene is not relevant for breast cancer prognosis.
|
14710228 |
2004 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate the association between the FGFR4 Gly388Arg polymorphism and breast cancer risk as well as clinicopathological parameters of the patients.
|
20066896 |
2009 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
A common single nucleotide polymorphism (SNP) Gly388Arg variant has been associated with increased tumor cell motility and progression of breast cancer, head and neck cancer and soft tissue sarcomas.
|
23226373 |
2012 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results of this study show that FGFR4 SNP rs351855 is associated with up-regulation of FGFR4 protein expression and a worse prognosis in breast cancer.
|
29603419 |
2018 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNPs rs1966265 and rs351855 in FGFR4 were associated with breast cancer in a northern Chinese population.
|
26431494 |
2015 |
|
CANCER PROGRESSION AND TUMOR CELL MOTILITY
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings establish a new role for the FGFR4-G388R polymorphism in pituitary oncogenesis, providing a rationale for targeting Src and STAT3 in the personalized treatment of associated disorders.
|
22174695 |
2011 |
|
Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Glycine (Gly) to Arginine (Arg) polymorphism at codon 388 (Gly388Arg), which encodes an amino acid in the transmembrane part of the FGFR4 gene, was reported to be associated with an increased risk in some carcinomas.
|
18756523 |
2008 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown.
|
17088904 |
2006 |
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stratified analysis by cancer type indicated the rs351855 G>A polymorphism was associated with an increased risk of breast and prostate cancer, but a decreased risk of lung cancer.
|
28445975 |
2017 |
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung.
|
19296538 |
2009 |
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
|
17519899 |
2007 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The FGFR4 Gly388Arg polymorphism is associated with cancer and cardiovascular diseases, but its association with hypertension is unclear.
|
28650667 |
2017 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
To discuss the association between FGFR4 gene polymorphism rs351855 (Glu388Aly) and the susceptibility and chemotherapeutic effect of cervical cancer infected by high-risk type HPV.
|
28870344 |
2017 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To discuss the association between FGFR4 gene polymorphism rs351855 (Glu388Aly) and the susceptibility and chemotherapeutic effect of cervical cancer infected by high-risk type HPV.
|
28870344 |
2017 |
|
Cholelithiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population.
|
22535390 |
2012 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer.
|
16012724 |
2005 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggested that the FGFR4 rs351855G/A (Gly388Arg) and rs147603016G/A polymorphisms could act as protective factors against CAD in the Chinese population and indicated that a single gene polymorphism could have diverse functions in different diseases.
|
22696188 |
2012 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggested that the FGFR4 rs351855 (Gly388Arg) polymorphism and AG haplotype (rs351855 and rs641101) could act as protective factors against CAD in the Chinese population and indicated that a single gene polymorphism could have diverse functions in different diseases.
|
22313031 |
2012 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggested that the FGFR4 rs351855G/A (Gly388Arg) and rs147603016G/A polymorphisms could act as protective factors against CAD in the Chinese population and indicated that a single gene polymorphism could have diverse functions in different diseases.
|
22696188 |
2012 |