|
CANCER PROGRESSION AND TUMOR CELL MOTILITY
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
G388R mutation of the FGFR4 gene is not relevant for breast cancer prognosis.
|
14710228 |
2004 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
G388R mutation of the FGFR4 gene is not relevant for breast cancer prognosis.
|
14710228 |
2004 |
|
Tumor Progression
|
|
0.030 |
GeneticVariation
|
BEFREE |
Three other nonparametric linear rank-tests particularly suitable for investigating possible relations between G388R mutation and early cancer progression were also used.
|
14710228 |
2004 |
|
Malignant neoplasm of prostate
|
|
0.780 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters.
|
16061909 |
2005 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters.
|
16061909 |
2005 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters.
|
16061909 |
2005 |
|
Prostate carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters.
|
16061909 |
2005 |
|
Adenocarcinoma of lung (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that FGFR4 Gly388Arg polymorphism may predict prognosis in lung adenocarcinoma.
|
16061909 |
2005 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer.
|
16012724 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer.
|
16012724 |
2005 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients.
|
16109476 |
2006 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients.
|
16109476 |
2006 |
|
Node-positive breast cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
A recent study presented first evidence that a single nucleotide polymorphism (SNP) at codon 388 of fibroblast growth factor receptor 4 (FGFR4) gene, causing a transmembrane domain missense mutation (Gly388Arg), is associated with disease outcome in node-positive breast cancer.
|
16822847 |
2006 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown.
|
17088904 |
2006 |
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown.
|
17088904 |
2006 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown.
|
17088904 |
2006 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types.
|
17519899 |
2007 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types.
|
17519899 |
2007 |
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
|
17519899 |
2007 |
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
|
17519899 |
2007 |
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
|
17519899 |
2007 |
|
Malignant neoplasm of prostate
|
|
0.780 |
GeneticVariation
|
UNIPROT |
Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.
|
18670643 |
2008 |
|
Malignant neoplasm of prostate
|
|
0.780 |
GeneticVariation
|
UNIPROT |
Our results indicate that the FGFR4 Arg allele of the Gly388Arg polymorphism and the G allele of the rs2011077 polymorphism have a significant impact on the development of prostate cancer and BPH, and the progression of prostate cancer in a Japanese population.
|
18756523 |
2008 |
|
Malignant neoplasm of prostate
|
|
0.780 |
GeneticVariation
|
BEFREE |
Our results indicate that the FGFR4 Arg allele of the Gly388Arg polymorphism and the G allele of the rs2011077 polymorphism have a significant impact on the development of prostate cancer and BPH, and the progression of prostate cancer in a Japanese population.
|
18756523 |
2008 |