|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs of MMP-9, rs3918242 in the promoter region and 3 nonsynonymous coding SNPs (rs3918252, rs17576, and rs2250889) were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 58 white patients for whom there was a clinical suspicion of GCA.
|
18512818 |
2008 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MMP-1 -1,607 1G/2G (rs1799750), MMP-2 -1,306 C/T (rs243865), and MMP-9 -1,562 C/T (rs3918242) polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assay in 157 patients diagnosed with knee osteoarthritis based on the criteria of American College of Rheumatology and in 84 controls in Mersin, Turkey.
|
18802702 |
2009 |
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MMP-9 rs3918242 functional polymorphism is not associated with susceptibility to SSc.
|
21455563 |
2011 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The common sequence variation in MMP-9 -1562 C>T (rs3918242), has been involved in cancer risk.
|
21717058 |
2012 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The common sequence variation in MMP-9 -1562 C>T (rs3918242), has been involved in cancer risk.
|
21717058 |
2012 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Higher plasma and tissue MMP-9 levels are found in obese; therefore, we evaluated if the functional C(-1562)T polymorphism (rs3918242) located in promoter region of the MMP-9 gene is associated with obesity in women.
|
22304569 |
2012 |
|
Pregnancy associated hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven clinically relevant polymorphisms of eNOS (T-786C, rs2070744, a variable number of tandem repeats in intron 4 and Glu298Asp, rs1799983), MMP-9 (C-1562T, rs3918242 and -90(CA)₁₃-₂₅, rs2234681) and VEGF (C-2578A, rs699947 and G-634C, rs2010963) were genotyped by TaqMan allelic discrimination assays or PCR and fragment separation by electrophoresis in 122 patients with PE, 107 patients with GH and a control group of 102 normotensive pregnant (NP) women.
|
22573202 |
2012 |
|
Paraseptal emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TGFB1 rs2241718 and MMP9 rs3918242 SNPs were associated with centrilobular emphysema (p = 0.022 and p = 0.008), and the TNF rs1800629 SNP with paraseptal emphysema (p = 0.017).
|
23734748 |
2013 |
|
Centriacinar Emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TGFB1 rs2241718 and MMP9 rs3918242 SNPs were associated with centrilobular emphysema (p = 0.022 and p = 0.008), and the TNF rs1800629 SNP with paraseptal emphysema (p = 0.017).
|
23734748 |
2013 |
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The combined genotype MMP2 -1306C/T (rs243865) allele T with MMP9 -1562C/T (rs3918242) allele T was found to increase BC risk (OR 2.00, 95% CI 1.10-3.62; P = 0.022).
|
23819551 |
2013 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The combined genotype MMP2 -1306C/T (rs243865) allele T with MMP9 -1562C/T (rs3918242) allele T was found to increase BC risk (OR 2.00, 95% CI 1.10-3.62; P = 0.022).
|
23819551 |
2013 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The combined genotype MMP2 -1306C/T (rs243865) allele T with MMP9 -1562C/T (rs3918242) allele T was found to increase BC risk (OR 2.00, 95% CI 1.10-3.62; P = 0.022).
|
23819551 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population.
|
23819814 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study was aimed to investigate the prognostic significance of the IL-18+183 A/G polymorphism (rs5744292), single and in coexistence with the matrix metalloproteinase (MMP)-9 -1562 C/T (rs3918242) polymorphism, in patients with stable coronary artery disease (CAD).
|
24040261 |
2013 |
|
Diabetic foot ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we aim to investigate that whether single nucleotide polymorphism (SNP -1562C>T) (rs3918242) in the promoter region of MMP-9 gene, which alters the transcriptional activity of MMP-9 is associated with type 2 diabetes and diabetic foot ulcers (DFUs).
|
24043671 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we aim to investigate that whether single nucleotide polymorphism (SNP -1562C>T) (rs3918242) in the promoter region of MMP-9 gene, which alters the transcriptional activity of MMP-9 is associated with type 2 diabetes and diabetic foot ulcers (DFUs).
|
24043671 |
2013 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, MMP9 rs3918242 T allele was associated with higher LDL-cholesterol levels, suggesting a link between lipid metabolism alteration and cardiovascular disease.
|
24291031 |
2014 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study indicated that the MMP-9 -1562 C/T polymorphism (rs3918242) was not associated with BD risk.
|
25639450 |
2015 |
|
Gingival Recession
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 -1562 C>T (rs3918242) promoter polymorphism as a susceptibility factor for multiple gingival recessions.
|
25738347 |
2016 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, rs3918242 and central obesity have synergistic effects on risk of NAFLD.
|
26097608 |
2015 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, decreased risk of non-alcoholic fat liver disease was found when MMP-2 rs243865 (TT/CT) genotype carriers compared with CC carrier ((Adjust)OR=0.65, 95% CI: 0.47, 0.72, P=0.000).Interactions of central obesity with rs3918242 was preliminarily found by GMDR, with a maximum prediction accuracy (67.61%) and a maximum Cross-validation Consistency (10/10).The unconditional logistic regression method indicated central obesity-positive subject with genotype TT/CT had 4.54 times risk of NAFLD compared to central obesity-negative subjects with genotype CC (OR(add)(a)=4.54, 95% CI: 2.81, 7.21, P(add)(a)=0.000), which further confirmed the interactions.
|
26097608 |
2015 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results indicate that both rs3918242 and rs243865 is associated with risk of NAF</span>LD.
|
26097608 |
2015 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 rs243865, MMP3 rs3025058, MMP7 rs11568818, and MMP9 rs3918242 polymorphisms, respectively, and the risk of cervical cancer.
|
26526578 |
2016 |