|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The rs3918242 polymorphism may be a susceptible predictor of susceptibility of IS.
|
31415895 |
2020 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study provides preliminary evidence that the MMP9 rs3918242 polymorphism is linked to a higher risk of IS, confirming the role of MMP9 in the pathophysiology of IS, with potentially important therapeutic implications.
|
30257242 |
2018 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Subgroup analysis by the type of stroke showed that MMP-9 gene rs3918242 polymorphism increased the risk of ischemic stroke.
|
30132967 |
2018 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
A statistically significant association between rs3918242 polymorphism and CAD was observed in allelic model (Odds ratio (OR) 1.34; 95% confidence interval (CI) 1.20-1.50; <i>p</i> < 0.00001), recessive model (OR 1.43; 95% CI 1.17-1.75; <i>p</i> = 0.0004), and in dominant model ( OR 1.36; 95% CI 1.20-1.53; <i>p</i> < 0.00001).
|
29507703 |
2018 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.
|
28390432 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Matrix metalloproteinase 9 (MMP9) -1562C>T (rs3918242) polymorphism has been proposed as a risk factor for coronary artery disease (CAD) with conflicting results.
|
28400830 |
2017 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Therefore, our meta-analysis suggested that MMP-9 rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
|
28258806 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The findings of this study suggest that the MMP9 rs3918242 polymorphism is associated with an elevated risk of ische</span>mic stroke and that this gene polymorphism interacts with BMI in the risk of ischemic stroke.
|
26782596 |
2016 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The TC+CC genotype of MMP9 rs3918242 was associated with an elevated risk of ischemic stroke in tobacco smokers, and the OR (95% CI) was 2.03 (1.11-3.74).
|
26617904 |
2015 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study was aimed to investigate the prognostic significance of the IL-18+183 A/G polymorphism (rs5744292), single and in coexistence with the matrix metalloproteinase (MMP)-9 -1562 C/T (rs3918242) polymorphism, in patients with stable coronary artery disease (CAD).
|
24040261 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population.
|
23819814 |
2013 |
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs.
|
29739236 |
2019 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, we also found that there is a statistically significant association between rs3918242 polymorphism and myocardial infarction (MI) in Asians with allelic model (OR 1.66; 95% CI 1.29-2.14; <i>p</i> < 0.0001), recessive model (OR 2.29; 95% CI 1.44-3.63; <i>p</i> = 0.004), and dominant (OR 1.74; 95% CI 1.29-2.35; <i>p</i> = 0.0003) model.
|
29507703 |
2018 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer.
|
28980922 |
2017 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.
|
28390432 |
2017 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
MMP9 rs3918242 TT genotype is associated with elevated serum TG and LDL-C, and enhanced LDL-C-lowering response upon simvastatin treatment in Chinese patients with CHD.
|
28390432 |
2017 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer.
|
28980922 |
2017 |
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we analyzed MMP1 -1607 1G/2G (rs1799750), MMP3 -1171 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms in relation to susceptibility to SSc and its clinical features.
|
28002595 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Since gene-environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C-1562T (rs3918242) functional variant and cigarette smoke in the pathogenesis of this disease.
|
27270564 |
2016 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |