|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 rs243865, MMP3 rs3025058, MMP7 rs11568818, and MMP9 rs3918242 polymorphisms, respectively, and the risk of cervical cancer.
|
26526578 |
2016 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 rs243865, MMP3 rs3025058, MMP7 rs11568818, and MMP9 rs3918242 polymorphisms, respectively, and the risk of cervical cancer.
|
26526578 |
2016 |
|
Psoriasis vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 gene polymorphisms (rs3918242, rs3918254 and rs4810482) and the risk of psoriasis vulgaris: No evidence for associations in a Chinese Han population.
|
26554609 |
2015 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The TC+CC genotype of MMP9 rs3918242 was associated with an elevated risk of ischemic stroke in tobacco smokers, and the OR (95% CI) was 2.03 (1.11-3.74).
|
26617904 |
2015 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The findings of this study suggest that the MMP9 rs3918242 polymorphism is associated with an elevated risk of ische</span>mic stroke and that this gene polymorphism interacts with BMI in the risk of ischemic stroke.
|
26782596 |
2016 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P < 0.01).
|
26985929 |
2016 |
|
MYELODYSPLASTIC SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed to investigate mRNA expression and gelatinase A and B secretion from BM-MNCs in vitro and genotypic associations of MMP-2 (-1306 C/T; rs243865), MMP-9 (-1562 C/T; rs3918242), tissue inhibitor of metalloproteinase -1 (TIMP-1) (372T/C; rs4898, Exon 5) and TIMP-2 (-418G/C; rs8179090) in MDS and AML.
|
27039800 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed to investigate mRNA expression and gelatinase A and B secretion from BM-MNCs in vitro and genotypic associations of MMP-2 (-1306 C/T; rs243865), MMP-9 (-1562 C/T; rs3918242), tissue inhibitor of metalloproteinase -1 (TIMP-1) (372T/C; rs4898, Exon 5) and TIMP-2 (-418G/C; rs8179090) in MDS and AML.
|
27039800 |
2016 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the MMP9 expression of human atrial myocyte is associated with AF, our study did not support the association of susceptibility to AF among Taiwanese subjects with the MMP9 rs3918242 polymorphism.
|
27070579 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The result of the meta-analysis showed that MMP-9 rs3918242 C > T was significantly correlated with increased susceptibility to COPD.
|
27173221 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Since gene-environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C-1562T (rs3918242) functional variant and cigarette smoke in the pathogenesis of this disease.
|
27270564 |
2016 |
|
Diseases of mitral valve
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, rs3918242 MMP-9 and rs2285053 MMP-2 SNPs were significantly represented in cases than two control groups and were associated with a higher MVD risk, as demonstrated using dominant/recessive models.
|
27288746 |
2017 |
|
Rheumatic disease of mitral valve
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, rs3918242 MMP-9 and rs2285053 MMP-2 SNPs were significantly represented in cases than two control groups and were associated with a higher MVD risk, as demonstrated using dominant/recessive models.
|
27288746 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we analyzed MMP1 -1607 1G/2G (rs1799750), MMP3 -1171 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms in relation to susceptibility to SSc and its clinical features.
|
28002595 |
2016 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Therefore, our meta-analysis suggested that MMP-9 rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
|
28258806 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.
|
28390432 |
2017 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.
|
28390432 |
2017 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
MMP9 rs3918242 TT genotype is associated with elevated serum TG and LDL-C, and enhanced LDL-C-lowering response upon simvastatin treatment in Chinese patients with CHD.
|
28390432 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Matrix metalloproteinase 9 (MMP9) -1562C>T (rs3918242) polymorphism has been proposed as a risk factor for coronary artery disease (CAD) with conflicting results.
|
28400830 |
2017 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer.
|
28980922 |
2017 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |