|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events.
|
26386440 |
2015 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models.
|
22693556 |
2012 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD.
|
27807918 |
2017 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here we investigated the influence of the ADHD related risk alleles for rs4570625 and for rs11178997 on prefrontal brain function during cognitive response control in large samples of adult ADHD patients (n=124) and healthy controls (n=84).
|
18427560 |
2009 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study involving 64 individuals, we examined the associations between prefrontal cortical GABA concentration and 12 single nucleotide polymorphisms (SNPs) spanning the TPH2 gene, including rs4570625 (-703 G/T SNP), a potentially functional TPH2 polymorphism that has been associated with decreased TPH2 mRNA expression and panic disorder.
|
23552096 |
2013 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, rs4570625 may have a gender-dependent effect on susceptibility to PD.
|
19132526 |
2009 |
|
Anxiety
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety.
|
22835848 |
2013 |
|
Anxiety
|
|
0.020 |
GeneticVariation
|
BEFREE |
Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011).
|
26232682 |
2015 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis revealed a strong trend of association between the regulatory region SNPs (rs4570625, rs11178997) and ADHD (P=0.064).
|
16116490 |
2005 |
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety.
|
22835848 |
2013 |
|
Anxiety symptoms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, a haplotype that included the promoter rs4570625 polymorphism (associated with anxiety-related traits in previous studies) showed an association with the severity of anxiety symptoms on admission.
|
19361870 |
2009 |
|
Anxiety symptoms
|
|
0.020 |
GeneticVariation
|
BEFREE |
TPH2 rs4570625 GG carriers were more likely to achieve depressive and anxiety symptom remission compared with T-allele carriers.
|
26745768 |
2016 |
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011).
|
26232682 |
2015 |
|
Unipolar Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events.
|
26386440 |
2015 |
|
Obsessive-Compulsive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this first study of TPH2 in OCD, analysis of the SNPs, rs4570625 and rs4565946, revealed a significant preferential transmission of haplotype G-C to children and adolescents with OCD.
|
16146581 |
2006 |
|
Oppositional Defiant Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups.
|
27871272 |
2016 |
|
Autistic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
TPH2 alleles and haplotypes are not significantly associated in our sample with autism (rs4570625: TDT P = 0.27, and FBAT P = 0.35; rs4565946: TDT P = 0.45, and FBAT P = 0.55; haplotype P = 0.84), with any endophenotype, or with the presence/absence of prominent repetitive and stereotyped behaviors (motor stereotypies: P = 0.81 and 0.84, verbal stereotypies: P = 0.38 and 0.73 for rs4570625 and rs4565946, respectively).
|
17346350 |
2007 |
|
Impulsive Behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subjects with the TPH2 rs4570625 TT genotype, especially males, exhibit less aggression and a favourable impulsivity profile, and develop anxiety disorders by young adulthood less often.
|
28342337 |
2017 |
|
Epilepsy, Temporal Lobe
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the influence of the rs4570625 and rs17110747 polymorphisms in the TPH2 gene on psychiatric comorbidities in TLE.
|
24491795 |
2014 |
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single marker analyses showed a significant GxE interaction with several TPH2 variants, including rs4570625, on depressive symptoms.
|
22868061 |
2012 |
|
Tic disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys.
|
23360517 |
2013 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample.
|
28342337 |
2017 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In smaller sub-samples, the rare rs4570625-rs4565946 T-T haplotype was associated with reduced processing speed (n = 193, p = 0.004) and sensorimotor gating (n = 68, p = 0.006) of schizophrenia patients.
|
22655589 |
2012 |
|
recurrent muscle twitches (symptom)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys.
|
23360517 |
2013 |
|
Alcohol abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.
|
24491795 |
2014 |