|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis revealed a strong trend of association between the regulatory region SNPs (rs4570625, rs11178997) and ADHD (P=0.064).
|
16116490 |
2005 |
|
Obsessive-Compulsive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this first study of TPH2 in OCD, analysis of the SNPs, rs4570625 and rs4565946, revealed a significant preferential transmission of haplotype G-C to children and adolescents with OCD.
|
16146581 |
2006 |
|
Autistic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
TPH2 alleles and haplotypes are not significantly associated in our sample with autism (rs4570625: TDT P = 0.27, and FBAT P = 0.35; rs4565946: TDT P = 0.45, and FBAT P = 0.55; haplotype P = 0.84), with any endophenotype, or with the presence/absence of prominent repetitive and stereotyped behaviors (motor stereotypies: P = 0.81 and 0.84, verbal stereotypies: P = 0.38 and 0.73 for rs4570625 and rs4565946, respectively).
|
17346350 |
2007 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here we investigated the influence of the ADHD related risk alleles for rs4570625 and for rs11178997 on prefrontal brain function during cognitive response control in large samples of adult ADHD patients (n=124) and healthy controls (n=84).
|
18427560 |
2009 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, rs4570625 may have a gender-dependent effect on susceptibility to PD.
|
19132526 |
2009 |
|
Anxiety symptoms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, a haplotype that included the promoter rs4570625 polymorphism (associated with anxiety-related traits in previous studies) showed an association with the severity of anxiety symptoms on admission.
|
19361870 |
2009 |
|
Personality Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
By doing so, we observed nominal evidence for G x E effects as well as main effects of 5-HTT-LPR and the TPH2 SNP rs4570625 on the occurrence of personality disorders.
|
19894072 |
2010 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models.
|
22693556 |
2012 |
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single marker analyses showed a significant GxE interaction with several TPH2 variants, including rs4570625, on depressive symptoms.
|
22868061 |
2012 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In smaller sub-samples, the rare rs4570625-rs4565946 T-T haplotype was associated with reduced processing speed (n = 193, p = 0.004) and sensorimotor gating (n = 68, p = 0.006) of schizophrenia patients.
|
22655589 |
2012 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
An overrepresentation of T allele carriers of a functional polymorphism (G-703T, rs4570625) in the promoter region of TPH2 gene was observed in the progressive MS subtypes.
|
22698518 |
2012 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study involving 64 individuals, we examined the associations between prefrontal cortical GABA concentration and 12 single nucleotide polymorphisms (SNPs) spanning the TPH2 gene, including rs4570625 (-703 G/T SNP), a potentially functional TPH2 polymorphism that has been associated with decreased TPH2 mRNA expression and panic disorder.
|
23552096 |
2013 |
|
Anxiety
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety.
|
22835848 |
2013 |
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety.
|
22835848 |
2013 |
|
Tic disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys.
|
23360517 |
2013 |
|
recurrent muscle twitches (symptom)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys.
|
23360517 |
2013 |
|
Epilepsy, Temporal Lobe
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the influence of the rs4570625 and rs17110747 polymorphisms in the TPH2 gene on psychiatric comorbidities in TLE.
|
24491795 |
2014 |
|
Alcohol abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.
|
24491795 |
2014 |
|
Psychotic Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In patients with TLE, the presence of the T allele in the rs4570625 polymorphism was associated with psychotic disorders (OR=6.28; 95% CI=1.27-17.54; p=0.02), while the presence of the A allele in the rs17110747 polymorphism was associated with alcohol abuse (OR=20.33; 95% CI=1.60-258.46; p=0.02).
|
24491795 |
2014 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events.
|
26386440 |
2015 |
|
Anxiety
|
|
0.020 |
GeneticVariation
|
BEFREE |
Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011).
|
26232682 |
2015 |
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011).
|
26232682 |
2015 |
|
Unipolar Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events.
|
26386440 |
2015 |
|
Anxiety symptoms
|
|
0.020 |
GeneticVariation
|
BEFREE |
TPH2 rs4570625 GG carriers were more likely to achieve depressive and anxiety symptom remission compared with T-allele carriers.
|
26745768 |
2016 |
|
Oppositional Defiant Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups.
|
27871272 |
2016 |