rs4680, COMT;MIR4761

N. diseases: 155
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. 24389396 2014
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032 2014
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure. 22138198 2013
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene. 21231925 2011
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. 18384078 2008
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE Role of the COMT gene Val158Met polymorphism in mental disorders: a review. 17419009 2007
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.070 GeneticVariation BEFREE The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder. 16542182 2006