|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequency of haplotype rs4833095-rs5743557-rs5743596-rs5743604 CAAG was significantly higher in the healthy controls (HC) group (p = 0.0009), while frequency of haplotype CGGA was higher in the TB group (p = 0.001).
|
29454979 |
2018 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
An increased risk of TB was found for individuals with the TLR2 rs3804100 CC and the TLR9 rs352139 GA and GG genotypes, while decreased risk was identified for those with the AG genotype of TLR1 rs4833095.
|
26430737 |
2015 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequency of <i>TLR1</i> haplotype rs4833095-rs5743604 CG was significantly higher in the LTBI group than in the TB group (P=0.019877).
|
30963003 |
2019 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
There was increased tuberculosis risk associated with the haplotype CAG (rs4833095/rs76600635/rs5743596) [OR (95% CI) = 1.33 (1.07-1.65)] and with haplotype GG (rs56357984/rs5743557) [OR = 1.21 (1.02-1.43)].
|
29416723 |
2018 |
|
IGA Glomerulonephritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
After Bonferroni correction, the association of the genotypes of rs4833095 and the CT haplotype with IgAN risk remained significant.
|
21108742 |
2011 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions.
|
19456232 |
2009 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported.
|
23547143 |
2013 |
|
IGA Glomerulonephritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Taken together, these findings suggest that the TLR1 rs4833095 polymorphism may play a role in the development and progression of IgAN.
|
27806314 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
Invasive aspergillosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of recipient SNP data showed that the presence of TLR1 239G > C (Arg80 > Thr) or the presence of both TLR1 743A > G (Asn248 > Ser) and TLR6 745C > T (Ser249 > Pro) is associated with IA (odds ratio = 1.30, 95% confidence interval = 1.13 to 1.50; P < .001).
|
16461792 |
2005 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
After Bonferroni correction the homozygous variant genotype of TLR1 743 T > C (rs4833095) (odds ratios (OR): 2.59, 95% confidence interval (CI): 1.48-4.51, p = 0.04), and TNFRSF1A -609 G > T (rs4149570) (OR: 1.79, 95% CI: 1.31-2.41, p = 0.01) were associated with increased risk of AS and the combined homozygous and heterozygous variant genotypes of TNF -308 G > A (rs1800629) (OR: 0.56, 95% CI: 0.44-0.72, p = 0.0002) were associated with reduced risk of AS.
|
30208882 |
2018 |
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the odds of malaria-associated anaemia were more than doubled in TLR-1 S248N heterozygous women (P=0.03) although parasite densities did not differ.
|
20478407 |
2010 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We focussed on three single allelic variants, N248S in TLR1, Q11L in TLR7 and M1V in TLR8 based on the allelic frequencies in both patient and control populations, the predicted impact on protein function and the novelty in RA research.
|
28495399 |
2017 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Candidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of TLR SNPs revealed that 3 TLR1 SNPs (R80T, S248N, I602S) were significantly associated with candidemia susceptibility in whites.
|
22301633 |
2012 |
|
Intestinal metaplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
|
26698117 |
2015 |
|
Mycobacterium Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection.
|
23547143 |
2013 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
|
26698117 |
2015 |
|
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response.
|
30131804 |
2018 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two SNPs in TLR10 [I369L (rs11096955) and N241H (rs11096957)] and 4 SNPs in TLR1 [N248S (rs4833095), S26L (rs5743596), rs5743595 and rs5743551] were associated with a statistically significant reduced risk of prostate cancer of 29-38% (for the homozygous variant genotype).
|
18752252 |
2008 |