|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
Hay fever
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
Allergic Reaction
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
LEPROSY, SUSCEPTIBILITY TO, 5
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequency of <i>TLR1</i> haplotype rs4833095-rs5743604 CG was significantly higher in the LTBI group than in the TB group (P=0.019877).
|
30963003 |
2019 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequency of haplotype rs4833095-rs5743557-rs5743596-rs5743604 CAAG was significantly higher in the healthy controls (HC) group (p = 0.0009), while frequency of haplotype CGGA was higher in the TB group (p = 0.001).
|
29454979 |
2018 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
There was increased tuberculosis risk associated with the haplotype CAG (rs4833095/rs76600635/rs5743596) [OR (95% CI) = 1.33 (1.07-1.65)] and with haplotype GG (rs56357984/rs5743557) [OR = 1.21 (1.02-1.43)].
|
29416723 |
2018 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
An increased risk of TB was found for individuals with the TLR2 rs3804100 CC and the TLR9 rs352139 GA and GG genotypes, while decreased risk was identified for those with the AG genotype of TLR1 rs4833095.
|
26430737 |
2015 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
IGA Glomerulonephritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Taken together, these findings suggest that the TLR1 rs4833095 polymorphism may play a role in the development and progression of IgAN.
|
27806314 |
2016 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported.
|
23547143 |
2013 |
|
IGA Glomerulonephritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
After Bonferroni correction, the association of the genotypes of rs4833095 and the CT haplotype with IgAN risk remained significant.
|
21108742 |
2011 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions.
|
19456232 |
2009 |
|
Diabetic foot infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, patients with DFI hetero- or homozygous for the allelic variant TLR1 (S248N) had significantly larger lesions.
|
31786695 |
2020 |
|
Latent Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of <i>TLR1</i> haplotype rs4833095-rs5743604 CG was significantly higher in the LTBI group than in the TB group (P=0.019877).
|
30963003 |
2019 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
After Bonferroni correction the homozygous variant genotype of TLR1 743 T > C (rs4833095) (odds ratios (OR): 2.59, 95% confidence interval (CI): 1.48-4.51, p = 0.04), and TNFRSF1A -609 G > T (rs4149570) (OR: 1.79, 95% CI: 1.31-2.41, p = 0.01) were associated with increased risk of AS and the combined homozygous and heterozygous variant genotypes of TNF -308 G > A (rs1800629) (OR: 0.56, 95% CI: 0.44-0.72, p = 0.0002) were associated with reduced risk of AS.
|
30208882 |
2018 |
|
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response.
|
30131804 |
2018 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We focussed on three single allelic variants, N248S in TLR1, Q11L in TLR7 and M1V in TLR8 based on the allelic frequencies in both patient and control populations, the predicted impact on protein function and the novelty in RA research.
|
28495399 |
2017 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Intestinal metaplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
|
26698117 |
2015 |