rs4833095, TLR1

N. diseases: 28
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetic foot infection
CUI: C0744130
Disease: Diabetic foot infection
0.010 GeneticVariation BEFREE However, patients with DFI hetero- or homozygous for the allelic variant TLR1 (S248N) had significantly larger lesions. 31786695 2020
Latent Tuberculosis
CUI: C1609538
Disease: Latent Tuberculosis
0.010 GeneticVariation BEFREE The frequency of <i>TLR1</i> haplotype rs4833095-rs5743604 CG was significantly higher in the LTBI group than in the TB group (P=0.019877). 30963003 2019
Melioidosis
CUI: C0025229
Disease: Melioidosis
0.010 GeneticVariation BEFREE We conducted a genetic association study in 427 patients with melioidosis to determine the association of TLR1 variation with organ failure or death.We genotyped rs5743551 and rs4833095. 24392083 2014
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.010 GeneticVariation BEFREE Two SNPs in TLR10 [I369L (rs11096955) and N241H (rs11096957)] and 4 SNPs in TLR1 [N248S (rs4833095), S26L (rs5743596), rs5743595 and rs5743551] were associated with a statistically significant reduced risk of prostate cancer of 29-38% (for the homozygous variant genotype). 18752252 2008
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.010 GeneticVariation BEFREE Carrier frequencies of the minor alleles of TLR1 p.His305Leu (OR = 4.79, 95% CI = 2.35-9.75, P = 0.0002), TLR1 p.Asn248Ser (OR = 1.26, 95% CI = 1.07-1.47, P = 0.04) and TLR8 p.Met1Val (OR = 1.37, 95% CI = 1.14-1.64, P = 0.008) were significantly higher in patients with ESRD, with little specificity for the underlying renal disease entity (adjusted for age, gender and donor-recipient relatedness). 26445497 2015
Malignant neoplasm of breast
CUI: C0006142
Disease: Malignant neoplasm of breast
0.010 GeneticVariation BEFREE In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population. 26226228 2015
LEPROSY, SUSCEPTIBILITY TO, 5
CUI: C2750733
Disease: LEPROSY, SUSCEPTIBILITY TO, 5
0.700 SusceptibilityMutation CLINVAR
Asthma
CUI: C0004096
Disease: Asthma
0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Hay fever
CUI: C0018621
Disease: Hay fever
0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013