|
Adult Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings confirm that IDH, CIC, FUBP1 mutations and rs55705857 genotype are common in AO.
|
28388591 |
2017 |
|
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Childhood Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH1/2 mutated glioma has been associated with a germline risk variant, the rs55705857 G allele.
|
30823903 |
2019 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
We also adjusted for the recently discovered 8q24 glioma risk locus rs55705857 G allele.
|
23361564 |
2013 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10, OR = 3.54).
|
31277128 |
2019 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
|
29743610 |
2018 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
|
27282637 |
2016 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Taken into consideration the limitations of this study, the present findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma.
|
30778791 |
2019 |
|
Hereditary Malignant Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database.
|
30823903 |
2019 |
|
Low grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 × 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality.
|
23399484 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
After stratifying by histological and tumor genetic subtype, the most significant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or IDH2 (odds ratio (OR)=5.1, P=1.1×10(-31) and OR=4.8, P=6.6×10(-22), respectively).
|
22922872 |
2012 |