|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
After stratifying by histological and tumor genetic subtype, the most significant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or IDH2 (odds ratio (OR)=5.1, P=1.1×10(-31) and OR=4.8, P=6.6×10(-22), respectively).
|
22922872 |
2012 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Adult Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Childhood Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Well Differentiated Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
|
27282637 |
2016 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH1/2 mutated glioma has been associated with a germline risk variant, the rs55705857 G allele.
|
30823903 |
2019 |
|
Low grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 × 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality.
|
23399484 |
2013 |
|
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10, OR = 3.54).
|
31277128 |
2019 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently published research suggests that historically used clinical variables are not sufficient (and are likely inferior) prognostic and predictive indicators relative to information provided by recently discovered tumor markers (e.g., 1p/19q deletion and IDH1 or IDH2 mutation status), tumor expression profiles (e.g., the proneural profile) and/or constitutive genotype (e.g., rs55705857 on 8q24.21).
|
25552286 |
2015 |