|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distributions for the TLR-1 I602S differed significantly between patients with mild malaria and persons with asymptomatic infection.
|
18662133 |
2008 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54).
|
20617178 |
2010 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
Candidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of TLR SNPs revealed that 3 TLR1 SNPs (R80T, S248N, I602S) were significantly associated with candidemia susceptibility in whites.
|
22301633 |
2012 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).
|
23067142 |
2013 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).
|
23067142 |
2013 |
|
Gastric ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).
|
23067142 |
2013 |
|
Cystic Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.
|
23403223 |
2013 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported.
|
23547143 |
2013 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported.
|
23575331 |
2013 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
TLR1 G1805T is associated with increased TB in Africans and American Hispanics.
|
23691034 |
2013 |
|
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
|
Dermatitis, Atopic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR1 1805T/G showed statistical differences when the control (Hp-) and infected (Hp+) groups (P = 0.041*) were compared; the TLR1 1805G allele had a protective effect towards infection (OR = 0.1; 95% CI = 0.01-0.88, P = 0.033*).
|
24754375 |
2014 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).
|
24984237 |
2014 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant differences of the allelic and genotypic distributions of rs5743618 in TLR1 gene were observed between TB group and control group and, G allele of rs5743618 was associated with increased risk for TB (OR: 2.40, 95%CI: 1.41-4.07, P = 0.0009).
|
25544311 |
2015 |
|
Lyme Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the Arg753Gln single-nucleotide polymorphism (SNP) of the TLR2 gene, and the isoleucine to serine transversion at position 602 (Ile602Ser) of the TLR1 gene (previously associated with Lyme disease), in leptospirosis patients compared to healthy controls, carrying out a retrospective case/control study.
|
25784560 |
2015 |
|
Leptospirosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the present data suggest that the TLR2 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis and its severity.
|
25784560 |
2015 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants in TLR1 (I602S) and TLR6 (P249S) were genotyped by PCR-RFLP methods, and TLR2 (I/D) was genotyped by PCR in 200 samples each from uncomplicated malaria (UM) and severe malaria (SM).
|
26621243 |
2016 |
|
Asthma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.Mol Cancer Ther; 15(7); 1740-5.©2016 AACR.
|
27196764 |
2016 |
|
Secondary malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.
|
27196764 |
2016 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.Mol Cancer Ther; 15(7); 1740-5.©2016 AACR.
|
27196764 |
2016 |