|
Asthma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
We evaluated the association of TLR1 rs5743618 and TLR10 rs4129009 polymorphisms with asthma and asthma medication in 125 children aged 11-13 years.
|
28692144 |
2018 |
|
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
|
Eczema
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Respiratory Tract Diseases
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Childhood asthma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
TLR1 G1805T is associated with increased TB in Africans and American Hispanics.
|
23691034 |
2013 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample.
|
27998389 |
2016 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).
|
24984237 |
2014 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Stratification of the TB patients according to their bacillary load showed that the genotype 1805TT <i>TLR1</i> (rs5743618) was prevalent among paucibacillary patients [odds ratio (OR) = 0.38; 95% confidence interval (CI) = 0.19-0.76; <i>p</i> = 0.009] while the genotype 1805TG was common among multibacillary patients (OR = 3.72; CI = 1.65-8.4; <i>p</i> = 0.004).
|
29988507 |
2018 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant differences of the allelic and genotypic distributions of rs5743618 in TLR1 gene were observed between TB group and control group and, G allele of rs5743618 was associated with increased risk for TB (OR: 2.40, 95%CI: 1.41-4.07, P = 0.0009).
|
25544311 |
2015 |
|
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported.
|
23575331 |
2013 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54).
|
20617178 |
2010 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported.
|
23547143 |
2013 |
|
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response.
|
30131804 |
2018 |
|
Cystic Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.
|
23403223 |
2013 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).
|
23067142 |
2013 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).
|
23067142 |
2013 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants in TLR1 (I602S) and TLR6 (P249S) were genotyped by PCR-RFLP methods, and TLR2 (I/D) was genotyped by PCR in 200 samples each from uncomplicated malaria (UM) and severe malaria (SM).
|
26621243 |
2016 |
|
Lyme Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the Arg753Gln single-nucleotide polymorphism (SNP) of the TLR2 gene, and the isoleucine to serine transversion at position 602 (Ile602Ser) of the TLR1 gene (previously associated with Lyme disease), in leptospirosis patients compared to healthy controls, carrying out a retrospective case/control study.
|
25784560 |
2015 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
|
Candidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of TLR SNPs revealed that 3 TLR1 SNPs (R80T, S248N, I602S) were significantly associated with candidemia susceptibility in whites.
|
22301633 |
2012 |
|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distributions for the TLR-1 I602S differed significantly between patients with mild malaria and persons with asymptomatic infection.
|
18662133 |
2008 |