|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive.
|
27267363 |
2016 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.
|
19896331 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice.
|
30992540 |
2019 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (val66met) in the brain derived neurotrophic factor (BDNF) gene has been shown to be a risk factor for a number of psychiatric disorders, including schizophrenia.
|
20957650 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein.
|
19603419 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
|
29288952 |
2018 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.
|
17217930 |
2007 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies.
|
24051499 |
2013 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (rs6265) in the human gene, resulting in a valine to methionine substitution in the pro-BDNF protein, was thought to associate with psychiatric disorders and might play roles in the individual difference of cognitive abilities.
|
19424874 |
2009 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity.
|
24708359 |
2015 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the valine/methionine variant at codon 66 (Val66Met) of brain derived neurotrophic factor (BDNF) has been reported inconsistently across a spectrum of psychiatric disorders.
|
18797396 |
2008 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Altered hippocampal volume, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and neuroticism have each been implicated in the etiology of psychiatric disorders, especially depression.
|
18548532 |
2009 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults.
|
26830347 |
2016 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein.
|
19603419 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
G196A, a common polymorphism of the BDNF gene, not only affects cognitive and motor processes, but also is associated with various psychiatric disorders.
|
20085561 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders.
|
15537879 |
2004 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders.
|
25824305 |
2015 |
|
Acute Cerebrovascular Accidents
|
|
0.020 |
GeneticVariation
|
BEFREE |
Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke.
|
25241287 |
2015 |
|
Acute Cerebrovascular Accidents
|
|
0.020 |
GeneticVariation
|
BEFREE |
Previous studies show that the BDNF Val66Met variant negatively affects motor learning and severity of acute stroke.
|
24523540 |
2014 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because the expression of BDNF is influenced by genetic polymorphisms, in this study we investigated the association between the BDNF polymorphism val66met and both the risk of depression in ACS and the treatment response.
|
26795846 |
2016 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
BDNF val66met polymorphism and depressive disorders in patients with acute coronary syndrome.
|
26795846 |
2016 |
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism may contribute to development of depressive symptomatology in patients undergoing stressful life events, such as diagnosis of acute leukemia and preparation for HSCT.
|
22652301 |
2013 |
|
Addictive Behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent studies showed an association between a functional polymorphism of BDNF gene (Val66Met) and the susceptibility to methamphetamine addiction.
|
25168604 |
2014 |