|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Mental disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
Together with the C(-1019)G (rs6295) variant, the Ile28Val (rs1799921), Arg219Leu (rs1800044) and Gly22Ser (rs1799920) variants have been investigated in possible associations with psychiatric disorders, also with no definitive results.
|
18047755 |
2008 |
|
Major depression, single episode
|
|
0.020 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Borderline Personality Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to determine whether a functional polymorphism of the 5-hydroxytryptamine(1A) receptor (5-HTR(1A)) gene C -1019 G (identity number: rs6295 G/C) is associated with structural changes of the amygdala in patients with BPD.
|
18387137 |
2008 |
|
Melancholia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together with the C(-1019)G (rs6295) variant, the Ile28Val (rs1799921), Arg219Leu (rs1800044) and Gly22Ser (rs1799920) variants have been investigated in possible associations with psychiatric disorders, also with no definitive results.
|
18047755 |
2008 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
On the other hand, we detected an association between rs6295 and MDD in the meta-analysis (P(Z)=0.0327).
|
19730445 |
2009 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
|
Suicidal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Schizophrenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Huang and colleagues reported that rs6295 in HTR1A was associated with schizophrenia.
|
19747927 |
2010 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Mental disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders.
|
19997044 |
2010 |
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Personality Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Adult attention deficit hyperactivity disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Cluster C personality disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Cluster B personality disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |