|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
The G/C single-nucleotide polymorphism in the serotonin 1a receptor promoter, rs6295, has previously been linked with depression, suicide and antidepressant responsiveness.
|
26926882 |
2016 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
The G/C single-nucleotide polymorphism in the serotonin 1a receptor promoter, rs6295, has previously been linked with depression, suicide and antidepressant responsiveness.
|
26926882 |
2016 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
The G/C single-nucleotide polymorphism in the serotonin 1a receptor promoter, rs6295, has previously been linked with depression, suicide and antidepressant responsiveness.
|
26926882 |
2016 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
|
19997044 |
2010 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning.
|
28608854 |
2017 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The G-allele of rs6295 is known to be associated with aspects of major depression and migraine.
|
23333373 |
2013 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The most replicated findings are the associations between rs6295 (HTR1A gene) G allele or G/G genotype and rs6311 (HTR2A gene) A allele or A/A genotype and MD or depressive symptoms.
|
23547754 |
2013 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |