|
Premenstrual Dysphoric Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
As the G/G genotype of HTR1A (rs6295) involves in reducing serotonin neurotransmission, our results provide insight into the serotonin mechanism of cognitive function among women with PMDD.
|
24158751 |
2014 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association studies with the functional HTR1A promoter polymorphism rs6295 suggest a new model for the role of the 5-HT1A receptor in susceptibility to depression involving early deficits in cognitive, fear and stress reactivity as stressors that may ultimately lead to depression.
|
24180393 |
2014 |
|
psychiatric hospitalization
|
|
0.010 |
GeneticVariation
|
BEFREE |
First, we genotyped a cohort of 1412 individuals, randomly split into discovery and replication cohorts, to examine the relationship between rs6295 and five psychiatric outcomes: history of psychiatric hospitalization, history of suicide attempts, history of substance or alcohol abuse, current posttraumatic stress disorder (PTSD), current depression.
|
26926882 |
2016 |
|
Post-Traumatic Stress Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
First, we genotyped a cohort of 1412 individuals, randomly split into discovery and replication cohorts, to examine the relationship between rs6295 and five psychiatric outcomes: history of psychiatric hospitalization, history of suicide attempts, history of substance or alcohol abuse, current posttraumatic stress disorder (PTSD), current depression.
|
26926882 |
2016 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
For 5-HTTLPR and HTR1A rs6295, there was no significant main effect of each genotype on panic disorder alone.
|
23635830 |
2013 |
|
Seizures
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the good-fitting SEM, adjusting for confounding variables (e.g., age and PSS levels), revealed a significant pathway linking rs6295 variant to BAI scores via HF index modulation.
|
29363117 |
2018 |
|
Depression, Bipolar
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygote carriers of the rs6295 G variant reported less stressful events before current hospitalization for bipolar depression, but not in early life.
|
21397953 |
2011 |
|
Schizophrenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Huang and colleagues reported that rs6295 in HTR1A was associated with schizophrenia.
|
19747927 |
2010 |
|
Bipolar Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, we detected an association between rs6295 and B</span>P in the meta-analysis (fixed model: P(Z)=0.000400).
|
20594600 |
2011 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Completed Suicide
|
|
0.010 |
GeneticVariation
|
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Epilepsy, Temporal Lobe
|
|
0.010 |
GeneticVariation
|
BEFREE |
In order to address a potential role of rs6295 variants in human brain tissue, we have isolated DNA and mRNA from fresh frozen hippocampal tissue of pharmacoresistant temporal lobe epilepsy (TLE) patients (n=140) after epilepsy surgery for seizure control.
|
23333373 |
2013 |
|
Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In order to address a potential role of rs6295 variants in human brain tissue, we have isolated DNA and mRNA from fresh frozen hippocampal tissue of pharmacoresistant temporal lobe epilepsy (TLE) patients (n=140) after epilepsy surgery for seizure control.
|
23333373 |
2013 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Depressive disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Mental Depression
|
|
0.070 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Major depression, single episode
|
|
0.020 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Melancholia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Depressed mood
|
|
0.070 |
GeneticVariation
|
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |