|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk allele frequencies (RAF) of APOE rs7412, CXCL12 rs1746048, 9p21 rs10757274, MIA3 rs17465637 and SORT1 rs646776 were significantly higher in the PCAD cases as compared to the controls.
|
28705542 |
2019 |
|
Peripheral Arterial Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study strongly supports that genotypes of rs599839, rs646776 and rs12740374 on 1p13 are protective factors for diabetic PAD in a Chinese population.
|
29356453 |
2018 |
|
Coronary Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients.
|
25969834 |
2015 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a representative cohort of Asian Indians selected from the Indian Atherosclerosis Research Study.
|
24674750 |
2014 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a representative cohort of Asian Indians selected from the Indian Atherosclerosis Research Study.
|
24674750 |
2014 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the influence of rs5848 and rs646776 polymorphisms in both serum GRN level and risk for common neurodegenerative diseases, we studied 304 patients with Parkinson's disease (PD), 217 individuals with Alzheimer's disease, 131 subjects with mild cognitive impairment, and 126 controls.
|
23398167 |
2013 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Reduced circulating GRN levels might be associated with PD risk by pathogenic factors different from rs5848 and rs646776 polymorphisms.
|
23398167 |
2013 |
|
Neurodegenerative Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the influence of rs5848 and rs646776 polymorphisms in both serum GRN level and risk for common neurodegenerative diseases, we studied 304 patients with Parkinson's disease (PD), 217 individuals with Alzheimer's disease, 131 subjects with mild cognitive impairment, and 126 controls.
|
23398167 |
2013 |
|
Frontotemporal Lobar Degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of rs646776 with plasma GRN levels was replicated in two independent series of 508 controls (p = 1.9 × 10⁻¹⁹) and 197 FTLD patients (p = 6.4 × 10⁻¹²).
|
21087763 |
2010 |
|
Carotid Artery Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that two loci, chromosome 1p13.3 near CELSR2 and PSRC1 which contains rs646776, and 19q13.2 near TOMM40 and APOE which contains rs2075650, harbor risk alleles for CAAD.
|
19951432 |
2009 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Catalase measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Connecting genetic risk to disease end points through the human blood plasma proteome.
|
28240269 |
2017 |
|
C-reactive protein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.
|
27286809 |
2016 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Squamous cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
|
Pseudocholinesterase Measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
|
21943158 |
2011 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
19060911 |
2009 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|
19060910 |
2009 |
|
Lipids measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
|
19936222 |
2009 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
18193044 |
2008 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
SNPs rs599839 and rs646776 both explained around 1% of the variation in circulating LDL-cholesterol concentrations and were associated with about 15% of an SD change in LDL cholesterol per allele, assuming an SD of 1 mmol/L.
|
18262040 |
2008 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |