|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore investigated the association between ACE I/D, AGT M235T, and AT1 A1266C gene polymorphisms and early signs of target organ damage in 215 untreated patients with essential hypertension (EH).
|
10652033 |
2000 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we examined the genotype frequencies of the insertion/deletion polymorphisms of the ACE gene and the M235T polymorphism of the Angiotensinogen (Agt) gene in patients with essential hypertension in comparison with normotensive subjects.
|
9524045 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study shows that M235T and T174M variants are not associated either with essential hypertension or with target organ damage in a Spanish sample.
|
9607382 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the interaction of the I/D ACE and M235T AGT polymorphic alleles can contribute to essential hypertension, despite the absence of single gene associations with the condition.
|
9607178 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the linkage of essential hypertension to the angiotensinogen locus but do not indicate a specific role for the M235T variant.
|
9314412 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The molecular variant M235T, but not T174M, of the AGT gene is associated significantly with essential hypertension in this Taiwanese population.
|
9218179 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen (AGT) gene M235T variant is associated with essential hypertension and elevated plasma AGT concentrations, although the underlying mechanisms are unknown.
|
9403548 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension.
|
9170002 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that C-18T polymorphism in AGCE1 is a genetic risk factor for essential hypertension in the Japanese and is more tightly and directly associated with hypertension than TT/M235T.
|
9314411 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, we reported evidence for genetic linkage between human essential hypertension and the angiotensinogen gene (AGT) and an association with a common molecular variant of this gene (methionine 235 --> threonine or T235).
|
8728297 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of a polymorphism encoding threonine instead of methionine (M235T) has been associated not only with increased plasma angiotensinogen concentration but also with essential hypertension.
|
8593944 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, variation in the number of M235T alleles did not make a significant contribution to predicting the probability of having essential hypertension, either alone or in conjunction with other predictor variables.
|
7649545 |
1995 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two molecular variants of the angiotensinogen gene, one encoding threonine instead of methionine at position 235 (M235T) and the other encoding methionine rather than threonine at position 174 (T174M), were also tested for possible association with essential hypertension.
|
8177268 |
1994 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, if the Met235-->Thr variant of AGT is involved in essential HT, then its contribution may be, at best, much weaker in other HT groups.
|
8267622 |
1993 |