|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both variant alleles were associated with decreased prevalence of obesity (P<0.05); odds ratio 0.75 (0.61-0.93) per carried Ile-allele for rs738409 and 0.80 (0.64-1.00) per carried G-allele for rs2072907.
|
18728122 |
2008 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our aims were to develop a method to accurately predict non-alcoholic fatty liver disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data and to test whether knowledge of the recently discovered genetic variant in the PNPLA3 gene (rs738409) increases accuracy of the prediction.
|
19524579 |
2009 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele carriers of the SNP rs738409 had higher liver fat (P < 0.0001) and an odds ratio of 2.38 (95% CI 1.37-4.20) for having fatty liver compared to C allele homozygotes.
|
19651814 |
2009 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele carriers of the SNP rs738409 had higher liver fat (P < 0.0001) and an odds ratio of 2.38 (95% CI 1.37-4.20) for having fatty liver compared to C allele homozygotes.
|
19651814 |
2009 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs738409 G allele was significantly associated with NAFLD (P < 0.001; OR 2.8 95%, CI 1.5-5.2), independent of age, sex, body mass index (BMI), and Homeostasis Model Assessment (HOMA) index.
|
19738004 |
2009 |
|
Obesity, Morbid
|
|
0.020 |
GeneticVariation
|
BEFREE |
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.
|
19844213 |
2010 |
|
Liver Cirrhosis, Alcoholic
|
|
0.790 |
GeneticVariation
|
BEFREE |
We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).
|
19946271 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis.
|
20034933 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.
|
20373368 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis.
|
20373368 |
2010 |
|
Nonalcoholic Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis.
|
20373368 |
2010 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.
|
20373368 |
2010 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four hundred and seventy-five obese/overweight children and adolescents were genotyped for the I148M allele.
|
20546964 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2.11-7.21; P = 3.6 x 10(-43)).
|
20648472 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)).
|
20648472 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 polymorphism is associated with steatosis severity, hepatocellular ballooning, lobular inflammation, and perivenular fibrosis in pediatric NAFLD.
|
20648474 |
2010 |
|
Fatty Liver Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Interestingly, the rs738</span>409 G allele was strongly associated with the severity of steatosis (P < 0.0001), the presence of NASH (P < 0.0001), hepatocellular ballooning (P < 0.0001), lobular inflammation (P < 0.0001), and the presence of fibrosis (P = 0.01) independently of confounders.
|
20648474 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 polymorphism is associated with steatosis severity, hepatocellular ballooning, lobular inflammation, and perivenular fibrosis in pediatric NAFLD.
|
20648474 |
2010 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the rs738409 C>G adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism, which encodes the I148M protein variant in the catalytic domain, has been associated with severe steatosis, NASH, and liver fibrosis in adults.
|
20648474 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjustment for age, sex, diabetes, and alcohol consumption, the minor allele of rs738409 C/G, a nonsynonymous coding SNP in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene encoding an Ile148Met change, was associated with steatosis (P = 0.03), portal inflammation (P = 2.5 x 10(-4)), lobular inflammation (P = 0.005), Mallory-Denk bodies (P = 0.015), NAFLD activity score (NAS, P = 0.004), and fibrosis (P = 7.7 x 10(-6)).
|
20684021 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this large cohort of histologically proven NAFLD, we confirm the association of the rs738409 G allele with steatosis and describe its association with histological severity.
|
20684021 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
This study confirms that in people with type 2 diabetes, LFC is related to rs738409 polymorphism.
|
20826584 |
2010 |
|
Metabolic Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
The lack of a relationship with visceral obesity and the inverse correlation with CIMT suggest that fatty liver associated with the minor G allele of the PNPLA3 rs738409 polymorphism may not be linked to metabolic disorders.
|
20826584 |
2010 |