|
Respiratory Tract Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism is associated with NAFLD severity and the PNPLA3 gene is expressed in the kidneys, but whether PNPLA3 rs738409 polymorphism is also associated with renal tubular injury (RTI) is uncertain.
|
31519069 |
2020 |
|
Renal tubular injury
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism is associated with NAFLD severity and the PNPLA3 gene is expressed in the kidneys, but whether PNPLA3 rs738409 polymorphism is also associated with renal tubular injury (RTI) is uncertain.
|
31519069 |
2020 |
|
Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age.
|
31527889 |
2019 |
|
alcohol-related liver disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently, rs72613567:TA in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) was shown to be associated with a reduced risk for developing alcohol-related liver disease and to attenuate the risk associated with PNPLA3 rs738409:G. This study explores the risk-associations between these two genetic variants and the development of alcohol-related cirrhosis and HCC.
|
31630428 |
2019 |
|
Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The I148M variant of the Patatin-like phospholipase domain-containing 3 (PNPLA3) protein is associated with an increased risk for liver inflammation and hepatocellular carcinoma (HCC), but the underlying mechanism is unknown.
|
31637480 |
2019 |
|
Prediabetes syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 I148M is associated with increased risk of prediabetes, metabolic syndrome and insulin resistance in obese patients with NAFLD.
|
31826069 |
2019 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals.
|
30763699 |
2019 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
|
0.010 |
GeneticVariation
|
BEFREE |
Human immunodeficiency virus (HIV)-induced metabolic abnormalities and antiretroviral therapy (ART), genetic factors, most importantly the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain containing 3 (PNPLA3)-gene, as well as hepatitis C virus (HCV) coinfection may all cause hepatic steatosis (HS).
|
31067123 |
2019 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Accordingly, the naringenin-betaine cocrystals showed improved anti-hyperlipidemia effects on the C57 BL/6J PNPLA3 I148M transgenic mouse hyperlipidemia model.
|
30771018 |
2019 |
|
Chronic Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that PNPLA3 rs738409 G allele carriage may be associated with a faster progression of HCV cirrhosis to chronic liver failure.
|
31527889 |
2019 |
|
End Stage Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that PNPLA3 rs738409 G allele carriage may be associated with a faster progression of HCV cirrhosis to chronic liver failure.
|
31527889 |
2019 |
|
HCV coinfection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Human immunodeficiency virus (HIV)-induced metabolic abnormalities and antiretroviral therapy (ART), genetic factors, most importantly the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain containing 3 (PNPLA3)-gene, as well as hepatitis C virus (HCV) coinfection may all cause hepatic steatosis (HS).
|
31067123 |
2019 |
|
Posterior subcapsular cataract
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC.
|
30161167 |
2018 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1.
|
30327483 |
2018 |
|
Chronic viral hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent major genetic risk factors for progressive liver injury in nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and chronic viral hepatitis.
|
30161167 |
2018 |
|
22q13.3 Deletion Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variability in Phelan-McDermid syndrome: The impact of the PNPLA3 p.I148M polymorphism.
|
30308089 |
2018 |
|
POLYDACTYLY, POSTAXIAL, WITH PROGRESSIVE MYOPIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
Screening for the p.I148M variant can identify PMS patients at higher risk for liver dyfunction and help designing personalized therapeutic protocols.
|
30308089 |
2018 |
|
Celiac Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease.
|
30189691 |
2018 |
|
Primary sclerosing cholangitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC.
|
30161167 |
2018 |
|
Premenstrual syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Screening for the p.I148M variant can identify PMS patients at higher risk for liver dyfunction and help designing personalized therapeutic protocols.
|
30308089 |
2018 |
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results suggest that the I148M/PNPLA3 (rs738409) polymorphism is associated with the presence of pCAD in T2DM patients and with some cardiometabolic parameters.
|
27615511 |
2017 |
|
Insulin resistance syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The I148M variant in PNPLA3 and the E167K variant in TM6SF2 are both associated with increased liver fat content, but not features of the metabolic/insulin resistance syndrome.
|
27432073 |
2016 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 G allele carriers were found to be more susceptible to the metabolic-related hepatic steatosis, and developed NAFLD and liver fibrosis despite presenting relatively better metabolic statuses and lower risks for carotid atherosclerosis.
|
26765961 |
2016 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The PNPLA3 I148M (rs738409) genotype was performed by Taqman assays in 158 individuals from Southern Italy (namely, Catanzaro cohort) and in 207 individuals from Northern Italy (namely, Milan cohort) with a definite diagnosis of IBD.
|
26355465 |
2016 |
|
Renal Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
The patatin-like phospholipase 3 (PNPLA3) polymorphism rs738409 (c.444C>G) is associated with the risk of NAFLD and/or renal dysfunction; however, the influence of the weight status on the associations remains unknown.
|
26200108 |
2015 |