|
Obesity, Morbid
|
|
0.020 |
GeneticVariation
|
BEFREE |
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.
|
19844213 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene.
|
21665509 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.
|
24828988 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants.
|
27576208 |
2016 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
NAFLD association of PNPLA3 rs738409 was more pronounced among lean individuals (one-tailed p < 0.05) compared to the whole cohort sample.
|
30539516 |
2019 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Steatosis, ballooning, and lobular inflammation each were associated independently with significant fibrosis (P < .001); age, adiposity, fasting hyperglycemia, and the PNPLA3 I148M variant also were associated with fibrosis.
|
30708111 |
2019 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
|
0.010 |
GeneticVariation
|
BEFREE |
Human immunodeficiency virus (HIV)-induced metabolic abnormalities and antiretroviral therapy (ART), genetic factors, most importantly the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain containing 3 (PNPLA3)-gene, as well as hepatitis C virus (HCV) coinfection may all cause hepatic steatosis (HS).
|
31067123 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents.
|
31255630 |
2019 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
Metabolic Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.
|
26148225 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.
|
26765961 |
2016 |
|
Metabolic Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.
|
26765961 |
2016 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A genetic polymorphism in rs738409, in the patatin-like phospholipase domain-containing 3 gene (PNPLA3), is strongly associated with appearance of in NAFLD.
|
25678388 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis.
|
26389885 |
2015 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis.
|
26389885 |
2015 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A genetic variant of patatin-like phospholipase domain-containing 3 (PNPLA3-I14</span>8M) is the most prominent heritable factor associated with NAFLD.
|
29286303 |
2017 |
|
Liver Cirrhosis, Alcoholic
|
|
0.790 |
GeneticVariation
|
GWASCAT |
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
|
26482880 |
2015 |
|
Portal cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
|
26482880 |
2015 |
|
Hepatitis B
|
|
0.730 |
GeneticVariation
|
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Fatty Liver Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
A missense variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known.
|
29555681 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A nonsynonymous single nucleotide polymorphism rs738409 (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the literature.
|
23176674 |
2012 |
|
Pediatric Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity.
|
22140488 |
2011 |