Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively).
|
27852544 |
2016 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
|
22269120 |
2012 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD.
|
22065112 |
2012 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking.
|
27022745 |
2016 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
|
24885273 |
2014 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample.
|
22095036 |
2012 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We could confirm the susceptibility of STAT3 rs744166 TT homozygotes for UC (OR: 1.483, 95% CI: 1.103-1.992, P = 0.009).
|
22269120 |
2012 |
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Allele A of STAT3 SNP rs744166 A>G was significantly more frequent in both HT and GD patients, while allele G was significantly more frequent in the control group.
|
26204395 |
2015 |
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer.
|
26063618 |
2015 |
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China.
|
29330562 |
2018 |
Gastritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs744166 polymorphism (p = 0.001; OR = 1.64; 95 % CI = 1.16-2.31) and infection with H. pylori CagA-positive strains possessing higher number of EPIYA-C segments (p = 0.001; OR = 2.28; 95 % CI = 1.41-3.68) were independently associated with gastric cancer in comparison with gastritis.
|
26186918 |
2015 |
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer.
|
26063618 |
2015 |
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |