|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively).
|
27852544 |
2016 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking.
|
27022745 |
2016 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
|
24885273 |
2014 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
|
22269120 |
2012 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD.
|
22065112 |
2012 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample.
|
22095036 |
2012 |
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASDB |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
|
Inflammatory Bowel Diseases
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
|
21150878 |
2011 |
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We could confirm the susceptibility of STAT3 rs744166 TT homozygotes for UC (OR: 1.483, 95% CI: 1.103-1.992, P = 0.009).
|
22269120 |
2012 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Allele A of STAT3 SNP rs744166 A>G was significantly more frequent in both HT and GD patients, while allele G was significantly more frequent in the control group.
|
26204395 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study provides evidence that STAT3 rs744166 G allele and infection with CagA-positive H. pylori with higher number of EPIYA-C segments are independent risk factors for gastric cancer.
|
26186918 |
2015 |
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |