Crohn Disease
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASDB |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNP (rs744166) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
|
20159113 |
2010 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
|
21150878 |
2011 |
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant decreased risk of NSCLC was observed for carriers of minor alleles rs4796793 (odds ratio (OR) = 0.68, 95% confidence interval (CI) = 0.51-0.92), rs7211777 (OR = 0.67, 95%CI = 0.50-0.90), rs12949918 (OR = 0.73, 95%CI = 0.54-0.97), rs744166 (OR = 0.69, 95%CI = 0.51-0.92), rs9912773 (OR = 0.75, 95%CI = 0.55-0.98), and rs3869550 (OR = 0.70, 95%CI = 0.53-0.94).
|
21948749 |
2011 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD.
|
22065112 |
2012 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample.
|
22095036 |
2012 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
|
22269120 |
2012 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We could confirm the susceptibility of STAT3 rs744166 TT homozygotes for UC (OR: 1.483, 95% CI: 1.103-1.992, P = 0.009).
|
22269120 |
2012 |
Arthritis, Psoriatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
A statistically significant association of the STAT3 rs744166(∗)G allele with PsA was observed (P-value=1.36×10(-3), OR 1.35).
|
23127549 |
2013 |
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the allele and genotypic distributions of rs744166 polymorphism showed no significant differences between patients with BD and control subjects (allelic P-value=0.80, OR 1.03).
|
23127549 |
2013 |
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population.
|
24864251 |
2014 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
|
24885273 |
2014 |
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs744166 in STAT3 was associated with colon cancer risk in two studies; however, the direction of the observation was reversed in TP53 mutant tumors possibly due to a nullification of the effect by mutant p53.
|
25132422 |
2014 |
Crohn Disease
|
|
0.870 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
Ulcerative Colitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
|
25286337 |
2014 |
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer.
|
26063618 |
2015 |