|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results showed significant associations of rs965513/rs944289 with PTC risk existed in overall population (for rs965513, A vs. G: OR 1.71 (1.56-1.86); for rs944289, T vs. C: OR 1.29 (1.23-1.37)).
|
24723258 |
2014 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our results confirm that the FOXE1 rs965513 SNP confers an increased risk for DTC in the German population, particularly allele "A" and the genotypes "AA" and "AG" for PTC.
|
24325646 |
2014 |
|
Primary differentiated carcinoma of thyroid gland
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results confirm that the FOXE1 rs965513 SNP confers an increased risk for DTC in the German population, particularly allele "A" and the genotypes "AA" and "AG" for PTC.
|
24325646 |
2014 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis of the DTC patients stratified for primary tumor stage (T1-T2, T3-T4), the absence or presence of regional lymph node metastases (N0, N1), for distant metastases (M0, M1), as well as for ITL, showed an association of rs965513 with stages T1-T2, T1-T3, N1, and absence of ITL.
|
24325646 |
2014 |
|
Neoplasm Metastasis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis of the DTC patients stratified for primary tumor stage (T1-T2, T3-T4), the absence or presence of regional lymph node metastases (N0, N1), for distant metastases (M0, M1), as well as for ITL, showed an association of rs965513 with stages T1-T2, T1-T3, N1, and absence of ITL.
|
24325646 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis of the DTC patients stratified for primary tumor stage (T1-T2, T3-T4), the absence or presence of regional lymph node metastases (N0, N1), for distant metastases (M0, M1), as well as for ITL, showed an association of rs965513 with stages T1-T2, T1-T3, N1, and absence of ITL.
|
24325646 |
2014 |
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis of the DTC patients stratified for primary tumor stage (T1-T2, T3-T4), the absence or presence of regional lymph node metastases (N0, N1), for distant metastases (M0, M1), as well as for ITL, showed an association of rs965513 with stages T1-T2, T1-T3, N1, and absence of ITL.
|
24325646 |
2014 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations.
|
25855579 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
These results explain the mechanism by which the risk allele of rs965513 predisposes to thyroid cancer.
|
25918370 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
For rs965513, individuals carrying the risk A allele, compared to individuals with the G allele, had 31 % higher risk of thyroid cancer (A vs. G: OR 1.31, 95 % CI 1.17-1.46).
|
26206751 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped rs965513 from PTC patients and measured gene expression levels by real-time RT-PCR in unaffected thyroid tissue and matched tumor.
|
25303483 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four GWAS-identified SNPs of papillary thyroid cancer (PTC), rs965513, rs944289, rs966423 and rs2439302, were genotyped in a case-control study of 838 patients with PTC and 501 patients with benign thyroid tumor (BTT) from the Chinese Han population.
|
25746573 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC</span>) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood.
|
25918370 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly, the rs965513 on the TTF2 can also elevate the risk of PTC significantly (GA vs GG, OR = 1.67, 95% CI = 1.07-2.59; AA+GA vs AA, OR = 1.37, 95% CI = 1.09-1.82; A vs G, OR = 1.29, 95% CI = 1.05-1.59).
|
26356687 |
2015 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
For the GWAS SNP rs965513 near FOXE1, an association was found between genotypes G/A and A/A, and risk of DTC.
|
25849217 |
2015 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
|
25879635 |
2015 |
|
Thyroid Neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
These results explain the mechanism by which the risk allele of rs965513 predisposes to thyroid cancer.
|
25918370 |
2015 |
|
Thyroid Neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
For rs965513, individuals carrying the risk A allele, compared to individuals with the G allele, had 31 % higher risk of thyroid cancer (A vs. G: OR 1.31, 95 % CI 1.17-1.46).
|
26206751 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.060 |
GeneticVariation
|
BEFREE |
For rs965513, individuals carrying the risk A allele, compared to individuals with the G allele, had 31 % higher risk of thyroid cancer (A vs. G: OR 1.31, 95 % CI 1.17-1.46).
|
26206751 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.060 |
GeneticVariation
|
BEFREE |
These results explain the mechanism by which the risk allele of rs965513 predisposes to thyroid cancer.
|
25918370 |
2015 |
|
Primary differentiated carcinoma of thyroid gland
|
|
0.050 |
GeneticVariation
|
BEFREE |
For the GWAS SNP rs965513 near FOXE1, an association was found between genotypes G/A and A/A, and risk of DTC.
|
25849217 |
2015 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We genotyped rs965513 from PTC patients and measured gene expression levels by real-time RT-PCR in unaffected thyroid tissue and matched tumor.
|
25303483 |
2015 |
|
Neoplasm Metastasis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, results of stratified analysis revealed that the risk effects of rs944289 and rs965513 were more overpowering in the subgroups of patients with MNG, as well as subjects without metastasis.
|
26356687 |
2015 |
|
Thyroid carcinoma
|
|
0.860 |
GeneticVariation
|
BEFREE |
The A allele of rs965513 polymorphism was shown to be highly associated with risk of thyr</span>oid cancer, with odds ratios of 1.58 (95% CI 1.32-1.90) in all populations, 1.65 (95% CI 1.31-2.07)) in Caucasian populations and 1.49 in Asian populations.
|
27191655 |
2016 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases.
|
27191655 |
2016 |