Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 20
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 38
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 34
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 75
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 27
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 15
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 12
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 30
PCNA P12004 proliferating cell nuclear antigen Nucleic acid binding 0.98 0.382 0.846 17
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 28
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 20
CDH1 P12830 cadherin 1 0.15 0.401 0.808 10
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 21
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 35
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
MME P08473 membrane metalloendopeptidase Enzyme 1.5E-18 0.407 0.808 12
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846 22
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 11