Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 27
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 53
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 51
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 32
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 39
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71