Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 353 57
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 324 57
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 762 56
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 220 56
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 839 55
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 470 55
CYP19A1 P11511 cytochrome P450 family 19 subfamily A member 1 Enzyme 1.7E-05 0.410 0.885 448 54
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1030 52
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 534 52
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846 323 52
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 130 52
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 698 51
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 886 50
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 852 49
CFH P08603 complement factor H 0.86 0.441 0.885 304 49
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 283 49
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846 231 49
UGT1A9 O60656 UDP glucuronosyltransferase family 1 member A9 5.4E-08 0.590 0.577 64 49
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 888 48
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 537 47
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 410 47
TCF7L2 Q9NQB0 transcription factor 7 like 2 1.00 0.485 0.846 192 47
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846 219 46